Quiznetik

Physical Pharmaceutics 2 | Set 2

1. In psedoplastic flow as shear stress increases, shear rate...............

Correct : C. Increases but not linear

2. Dilatant materials are frequently called as...............

Correct : B. shear-thickening systems

3. The Rheogram of thixotropic material determined by...................

Correct : C. Both of the above

4. ....... is the isothermal and moderately slow recovery on standing of material of which stability lost owing to shearing.

Correct : D. Thixotropy

5. ......is the alteration in the shape and the size of a body owing to applied external forces and internal forces.

Correct : A. Deformation

6. A wetting agent is included in the formulation of a suspension, particularly when the suspended particles:

Correct : A. are hydrophobic

7. For a flocculated suspension, one of the following criterion is satisfied or established

Correct : C. weak inter-particle attractions

8. In stokes’ relationship, a parameter that greatly changes the velocity of settling is:

Correct : C. radius of the particle

9. The protamine-zinc insulin suspension is prepared by a method viz.,:

Correct : A. altered pH precipitation

10. Methyl cellulose is a polymer, which is of a type:

Correct : D. non-ionic

11. For a flocculated suspension the degree of flocculation is observed to be one. The sedimentation volume is also 1 (one). These values, respectively, indicate the limits:

Correct : B. lower and upper

12. For an ideal suspension, the sedimentation volume should be:

Correct : A. equal to one

13. In case of suspensions, all statements below are true EXCEPT that:

Correct : B. it does not include a preservative

14. In practice, an acceptable suspension should have particles:

Correct : B. which can be readily re-dispersible after they settle

15. For oral administration of a suspension to a patient, which one of the factors is the most important?

Correct : A. acceptable color and odour

16. Which one of the following properties is applicable to suspensions?

Correct : C. rapid rate of sedimentation

17. Suspended particles become flocculated in a suspension, because:

Correct : A. attractive forces between particles are appreciable

18. Structured vehicle is included in the formulation of a suspension, in order to:

Correct : A. decrease the interfacial tension

19. In the preparation of a structured vehicle, which one of the following substances is used?

Correct : D. methyl cellulose

20. Which type of colloidal material is used commonly in the preparation of a structured vehicle?

Correct : B. hydrophilic

21. When charcoal powder is dusted on the surface of water, the contact angle (in degrees) that the charcoal exhibits is:

Correct : D. 180

22. A maximum sedimentation volume will be obtained when zeta potential is:

Correct : D. zero

23. A substance is dissolved in water. The suspension has exhibited a negative apparent zeta potential. Identify the related substance.

Correct : D. sulfaguanidine

24. Calcium hydrogen phosphate is dissolved in water. The apparent zeta potential initially is:

Correct : A. negative

25. Which one of these preparations is NOT qualified as a suspension.

Correct : D. vitamin B complex tonic as nutritional supplement

26. The ratio of the ultimate volume of sediment to the actual volume of sediment before settling is called

Correct : A. Sedimentation volume

27. The ratio of the sedimentation volume in case of flocculated suspension to the sedimentation volume in case of deflocculated suspension is called

Correct : B. Degree of flocculation

28. The size of dispersed particles in coarse dispersion ranges from

Correct : A. 1 µm to 100 µm.

29. Which of the following are the desired features of good suspension:

Correct : D. All of the above

30. In flocculated suspension, the rate of sedimentation is

Correct : B. More

31. If zeta potential of a suspension is high, then the system will be considered as

Correct : A. Deflocculation

32. Which of the following is/are the properties of flocculated suspension?

Correct : D. All of the above

33. The value of sedimentation volume (F) gives a knowledge about the____________of the suspension

Correct : A. physical stability

34. Suspension is example of

Correct : A. Biphasic liquid dosage form

35. Acetates and Citrates are

Correct : A. Buffering agent

36. In an emulsion, the velocity of sedimentation is found to be negative. It means that the creaming is:

Correct : D. in upward direction

37. The density of the dispersed phase is more than that of the dispersion medium. According to the Stokes' equation, the creaming is:

Correct : C. in downward direction

38. When oil and water are triturated together, the interfacial free energy was observed to be increased. What does it indicate?:

Correct : B. decrease in the stability

39. For a stable emulsion, the phase volume ratio is generally about:

Correct : B. 52/48

40. The HLB range of an emulsifier employed in the preparation of water-in-oil emulsion is:

Correct : A. 3 to 6

41. In case of emulsions, the viscosity immediately after preparation and during storage, respectively, will be:

Correct : C. lower and gradually decrease

42. The distribution of globules is not uniform in an emulsion. This stage is termed as:

Correct : D. creaming

43. An o/w microemulsion is prepared using a hydrophilic surfactant. The appearance of the microemulsion is:

Correct : A. intense white

44. Emulsions are defined as thermodynamically unstable systems. The events that follow sequentially towards instability are:

Correct : D. flocculation, creaming, coalescence and breaking

45. In the stability of emulsion, which instability step is prevented by emulsifiers?:

Correct : B. coalescence

46. An ‘emulsion within emulsion’ is designated as:

Correct : D. w/o/w

47. The main function of an emulsifier in the preparation of an emulsion is to:

Correct : A. develop a condensed membrane layer film

48. An emulsifier can be regarded as superior, if its mechanism of action is based on the principle of:

Correct : B. forming monomolecular adsorption film

49. An emulsifier is considered to be ideal, if it is soluble in:

Correct : C. both aqueous and oil phase

50. On commercial scale, emulsions are prepared by::

Correct : D. homogenization

51. Microemulsion is NOT considered to be a true emulsion, because:

Correct : C. immiscible phase is absent

52. A variety of factors would influence the rate of creaming in an emulsion. The factor open to formulation pharmacist is to regulate:

Correct : C. globule size

53. Normally preservatives are added to an emulsion. One of the following statements is true.

Correct : C. preservatives remain in the aqueous phase

54. For the formulation of w/o emulsion, the coalescence rate of:

Correct : C. o/w is greater than w/o coalescence rate

55. Auxiliary emulsifying agents are used to stabilize the emulsion. They act on the principle:

Correct : D. thickening the continuous phase

56. Emulsion have a ......... shelf life

Correct : A. short

57. Creaming is a.......... process

Correct : A. reversible

58. O/W emulsions normally cream .........

Correct : B. upward

59. Microemulsions contain globules of the size about .........

Correct : D. 0.01 micrometer

60. Downward creaming means ........ rate of sedimentation

Correct : A. negative

61. A mixture of span 20 and tween 20 forms....... type of emulsion

Correct : A. W/O

62. Density of oily phase increased by addition of .......

Correct : C. water

63. Near CMC, micelles of the surfactant molecules assume the shape of

Correct : A. spherical

64. Which one of the following emulsifier is used to stabilise the emulsion of W/O type

Correct : B. Span 20

65. Creaming in emulsion can be controlled by regulating

Correct : C. globule size

66. An emulsifier is considered to be ideal, if it is soluble in

Correct : C. A & B

67. In the stability of emulsion, which important instability step should be prevented?

Correct : B. Coalescence

68. Emulsions made with tweens are

Correct : B. O/W

69. The HLB system is used classify

Correct : C. Surfactants

70. Emulsion containing more than two phases are called as

Correct : B. Multiple emulsion

71. Emulsion is

Correct : D. B & C

72. Which of the following is/ are the theories of emulsification?

Correct : D. All of the above

73. Which of the following is not the cause of Instability in emulsion

Correct : D. Mottling

74. Which of the following is a reversible phenomenon

Correct : A. Creaming

75. The phase inversion occur due to

Correct : C. Both a and b

76. Which of the following is used as antioxidants for emulsified systems

Correct : D. All of the above

77. Which of the following is identification test for emulsion

Correct : D. All of the above

78. When an emulsion is exposed to ultra-violet radiations. If the continuous fluorescence is observed under microscope, then it is_____________ type emulsion.

Correct : A. w/o

79. Dry Gum Method is also known as

Correct : A. Continental method.

80. In Dry gum method, 4:2:1 consist of

Correct : A. 4 parts oil, 2 parts water, and 1 part emulsifier

81. The rheological property of emulsion can be controlled by

Correct : D. All of the above

82. The suspensions having particle size................... are categorized as coarse suspension.

Correct : A. Greater than ~1 mm

83. ............ exists when dispersed solid particles in a suspension retain change in relation their adjoining liquid medium.

Correct : B. Surface potential

84. The equal distribution of all the ions in solution retain by……

Correct : C. Both of the above

85. The flocculated suspension is one in which zeta potential of particle is…… .

Correct : C. -20 to+20 mV

86. ...... determines the movement of charged particles via a liquid under the impact of an applied potential difference.

Correct : A. Electrophoresis

87. ..........is produced by forcing a liquid to course through a stationary solid phase.

Correct : D. The streaming potential

88. The flocculated suspensions sediment.............

Correct : C. More quickly

89. ..........suspension involves individual particle settling.

Correct : B. Deflocculated

90. Structured vehicles are also termed as or..............

Correct : C. Both of the above

91. ....... is the concentration of globules at the top or bottom of the emulsion.

Correct : A. Creaming

92. Which of the following properties of a particle significantly affects the physical, chemical and biological properties of the drug?

Correct : D. surface area

93. It is difficult to express the size of particles in a meaningful diameter.

Correct : A. irregular in shape

94. The type of a particle diameter obtained largely depends on:

Correct : A. method by which it is determined

95. When cumulative percent frequency on a probability scale is plotted against logarithm of the particle size, 50 percent on the probability scale gives the powder particle diameter of:

Correct : C. geometric mean

96. Which one of these distributions is more important in the design of dosage forms?

Correct : D. weight

97. In the formulation development of emulsions and suspensions, what type of diameter is important?

Correct : D. stokes

98. Sieving method is used for size distribution analysis of powder. The disadvantage of this method is:

Correct : B. attrition of powder is possible

99. While using sedimentation method for size analysis, addition of a deflocculating agent to a suspension is necessary in order to:

Correct : C. prevent the aggregation

100. Stokes’ law cannot be used, if Reynolds number is more than:

Correct : A. 0.2