Quiznetik

Pharmaceutical Organic Chemistry 3 | Set 2

1. Which is the most reactive five membered heterocyclic compound?

Correct : A. Pyrrole

2. What is the product when thiophene reacts with Br2 in benzene?

Correct : C. 2,5-dibromothiophene

3. What is the product when pyrrole reacts with Br2 in ethanol?

Correct : B. 2,3,4,5-tetrabromopyrrole

4. What is the name of the following reaction?

Correct : B. Riemer tiemann reaction

5. What is the name of the following reaction?

Correct : A. Gattermann reaction

6. What will be the reagent used for the completion of the following reaction?

Correct : B. Dilute acid

7. Which heteroatom present in pyrrole?

Correct : B. Nitrogen

8. Which heteroatom present in Furan?

Correct : A. Oxygen

9. Which heteroatom present in thiophene?

Correct : D. Sulphur

10. Which compound is most basic?

Correct : C. Imidazole

11. Which is least basic compound?

Correct : B. Pyrrole

12. Which of the following solvents is a heterocyclic compound?

Correct : C. THF

13. Which of the followings statements is correct?

Correct : C. Pyridine is tertiary amine

14. What is the correct order of reactivity (most reactive first) of pyrrole, furan and thiophene towards electrophiles?

Correct : B. Pyrrole > Furan > Thiophene

15. Electrophilic substitution in furan usually occurs at:

Correct : C. The C2 atom

16. Nitration of pyrrole is best carried out using:

Correct : A. Acetyl nitrate

17. If you wanted to form 2,3,4,5-tetrabromopyrrole from pyrrole, which of the following conditions would be the best choice?

Correct : C. Br2 in the presence of radical initiator

18. Which statement about thiophene is incorrect?

Correct : D. Thiophene is more reactive than furan

19. Pyrrole undergoes sulfonation in presence of _______to produce pyrrole – 2 – sulfonic acid.

Correct : B. SO3 and pyridine

20. Pyrrole undergoes iodination in presence of Iodine and potassium iodide to produce_____.

Correct : C. Tetra iodo pyrrole

21. Oxidation of pyrrole in presence of chromium oxide (Cr2O3) and acetic acid produce_______.

Correct : A. Maleinimide

22. Pyrrole is reduced by using Zn and acetic acid to get product_______

Correct : B. 3 – pyrroline

23. Which product will be produced when pyrrole undergoes catalytic reduction in presence of hydrogen gas and Ni metal?

Correct : C. Pyrrolidine

24. Identify the given heterocyclic compound.

Correct : C. Pyrrole

25. Pyrrole potassium on treatment with CO2 under pressure give mixture of 2 and 3 pyrrole – carboxylic acid, identify the reaction.

Correct : A. Kolbe-Schmidt reaction

26. Pyrrole is heated with_________ to open the ring and form succinaldehyde dioxime.

Correct : D. Ethanolic hydroxylamine hydrochloride

27. Atorvastatin, drug useful in CVS disease, contain heterocyclic ring______.

Correct : B. Pyrrole

28. Bepridil, calcium channel blocker, contain heterocyclic ring_____

Correct : A. Pyrrole

29. Ondansetron, anti emetic drug, contain heterocyclic ring______.

Correct : B. Pyrrole

30. Which drug(s) possess pyrrole heterocyclic compound from the followings?

Correct : D. All of the above

31. Identify the following heterocyclic compound.

Correct : A. Furan

32. Complete the following reaction.

Correct : B. Furan

33. Which would be the intermediate in the following reaction?

Correct : C. Furoic acid

34. Which would be the product when furan undergoes sulfonation in the presence of SO3 and pyridine?

Correct : A. Furan – 2 – sulfolic acid

35. Which reagent is used for the nitration of furan?

Correct : B. Acetyl nitrate

36. Friedel craft acetylation of furan by using acetic anhydride is carried out in the presence of catalyst______.

Correct : C. BF3

37. Identify the reaction: when furan react with aryl diazonium chloride in the presence of strong alkali to produce 2 – aryl furan.

Correct : D. Gomberg reaction

38. Bromination of furan by using Br2 will produce_________.

Correct : D. None of the above

39. Identify the following reaction:

Correct : A. Cannizaro reaction

40. Identify the following reaction:

Correct : C. Benzoin condensation

41. Complete the reaction:

Correct : A. Br2

42. Furan on treatment with acid undergoes protonation and form________.

Correct : B. Polymeric product

43. Oxidation of furan produces_________.

Correct : D. Succinaldehyde

44. Catalytic reduction of furan gives______

Correct : C. Tetra hydro furan

45. Prazocin, sympatholytic drug contain__________heterocyclic ring.

Correct : A. Furan

46. Which drug of following does not contain furan ring?

Correct : B. Lorpiprazole

47. Amiodarone, antiarrhythmic agent, possess_________ heterocyclic ring.

Correct : B. Furan

48. From the followings, which drug contain furan heterocyclic ring?

Correct : D. All of the above

49. Ranitidine, H2 receptor antagonist, possess________heterocyclic ring.

Correct : D. Furan

50. Pilocarpine, cholinergic agonist, contains________heterocyclic ring.

Correct : A. Furan

51. Which heterocyclic ring is present in Diloxanide furoate, anti protozoal drug?

Correct : C. Furan

52. Which heterocyclic ring is present in Rofecoxib, NSAID?

Correct : B. Furan

53. Which is the following heterocyclic compound?

Correct : A. Thiophene

54. Complete the reaction:

Correct : C. Thiphene

55. What would be the product of following reaction?

Correct : A. Thiophene

56. What would be the appropriate reaction condition for the following reaction;

Correct : C. H2S/Al2O3/673K

57. What is not true about thiophene from the following sentences?

Correct : B. Thiophene contains oxygen heteroatom.

58. Which is the true statement from followings?

Correct : C. Both (a) & (b)

59. Thiophene shows electrophilic substitution reactions mainly at position___.

Correct : A. C2

60. Which condition is appropriate for the nitration of thiophene?

Correct : B. Nitric acid +acetic anhydride

61. Identify the reaction: When thiophene react with dimethyl formamide in the presence of POCl3, it will produce thiophene – 2 – carboxaldehyde.

Correct : D. Vilsmeir – Hoack reaction

62. Sulfonation of thiophene can be carried out by using______________.

Correct : C. Concentrated Sulphuric acid

63. Chloromethylation of thiophene is carried out with HCHO & HCl, it will produce_______.

Correct : A. 2- chloromethyl thiophene

64. Complete the reaction:

Correct : D. SO2Cl2

65. What will be the product of the following reaction?

Correct : A. 2- iodo thiophene

66. What will be the product of the following reaction?

Correct : C. 2 – bromo thiophene

67. Chlorination of thiophene by using Chlorine at 243K will form__________.

Correct : C. 2- chloro thiophene + 2,5- dichloro thiophene

68. Bromination of thiophene by using Bromine in benzene will produce________

Correct : D. 2,5 – di bromo thiophene

69. Identify the reaction:

Correct : B. Canizzaro reaction

70. What would be the reducing agent for the following reduction of thiophene?

Correct : A. Na + ammonia

71. Thiophene on catalytic reduction with large amount of palladium (Pd) gives_________.

Correct : D. Tetra hydro thiophene

72. Thiophene is reduced with Raney nickel (Ni) which results in removal of sulphur to form______.

Correct : C. n – Butane

73. Which drug(s) contain thiophene ring in its(their) structure?

Correct : D. All of the above

74. Which drug(s) contain thiophene ring in its(their) structure?

Correct : D. All of the above

75. Thiophene & its derivatives show following pharmacological activity.

Correct : D. All of the above

76. Clotiazepam, CNS active agent, possess __________ heterocyclic ring.

Correct : A. Thiophene

77. Ticlopidine, anticoagulant activity, contain _________ heterocyclic compound.

Correct : B. Thiophene

78. Which pharmacological effect is not produced by thiophene derivatives?

Correct : C. Coagulants

79. Thiophene probably undergoes to ___________ reaction.

Correct : A. Electrophilic substitution

80. Furan probably undergoes to ___________ reaction.

Correct : A. Electrophilic substitution

81. Pyrrole probably undergoes to ___________ reaction.

Correct : A. Electrophilic substitution