Quiznetik

Medicinal Chemistry 1 | Set 2

1. Diazepam gets metabolised into Hydroxydiazepam is example of

Correct : B. Oxidation at the carbon alpha to carbonyl and imino group

2. __________reaction is most common in drugs having ester or amide functional groups

Correct : C. Hydrolysis

3. UDPGA means....

Correct : B. Uridine diphospho -a- D glucuronic acid

4. Which of the following statement is false?

Correct : D. Whole animal kingdom have the common ability to produce D-glucuronic acid

5. Which enzyme is of the utmost importance for the 2nd step in the formation of Glucuronide?

Correct : A. Esterase

6. What is the site of first-pass metabolism before molecules reach systemic circulation?

Correct : D. Intestine

7. What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein?

Correct : C. Liver

8. What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?

Correct : A. Ames test

9. Which of the following are protein components of the cytochrome P450 system?

Correct : A. Heme protein CYP450

10. Which of the following statements is not true about cytochrome P450 enzymes?

Correct : A. They contain haem and magnesium.

11. What is not a xenobiotic?

Correct : C. Steroids

12. What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines?

Correct : B. CYP3A4

13. Which of the following is an antiarrhythmic drug that is a calcium channel blocker?

Correct : C. Nifedipine

14. What drug should not be given to a patient that is a poor CYP2D6 metabolizer?

Correct : A. Codeine

15. What injection is administered directly into systemic circulation causing rapid distribution?

Correct : B. Intravenous

16. Where is Protonsil converted to Sulfanilamide?

Correct : B. Gut

17. What are xenobiotics?

Correct : D. Anything that is not nutrients and enters the body through different routes

18. What is the active form of salicylic acid?

Correct : C. Salicylic acid

19. What is the inactive form of Codeine?

Correct : C. Morphine

20. Which of the following is the correct decreasing order of drug metabolism?

Correct : A. Liver > lungs > kidneys > intestine > placenta > skin > adrenals

21. Which one of the following is reactive and a known carcinogenic?

Correct : D. Arene oxide

22. Which of the following is not an example of a drug undergoing acetylation reaction?

Correct : B. Salicylic acids

23. The overall rate of biotransformation is higher in neonates and infants than in adults.

Correct : B. False

24. In comparison with children and young adults, elderly adults tend to have a reduced capacity to metabolize drugs.

Correct : A. True

25. What is enzyme induction?

Correct : A. The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals

26. Which of the following drugs has self -induction to stimulate their own metabolism?

Correct : C. Meprobamate

27. Alcohol is the inducer for which drug?

Correct : B. Pentobarbital

28. What is the name of the process where structurally same compounds compete for the same site on an enzyme to inhibit that?

Correct : D. Competitive inhibition

29. What is the name of the process where structurally different compounds interact with the enzyme and prevent the metabolism of the drug?

Correct : C. Non-competitive inhibition

30. What is the name of the process where the enzyme amount is decreases due to a decrease in enzyme synthesis?

Correct : B. Repression

31. What is the name of the process where due to nutritional deficiency an enzyme content is decreased?

Correct : A. Altered physiology

32. Which one of the following is not an environmental agent to decrease drug metabolizing ability?

Correct : D. Methacholine

33. What is polygenic control of drugs?

Correct : B. Drug controlling seen in twins

34. Differences observed in metabolism of drug among different races is known as

Correct : B. Ethnic variations

35. Which age group is known as the neonates?

Correct : A. Up to 2 months

36. Which age group metabolizes drugs faster than the adults?

Correct : A. Between 1-12 year

37. Fat-free diet depresses cytochrome P-450 level.

Correct : A. True

38. Maternal drug metabolizing ability increases in the later stage of pregnancy.

Correct : B. False

39. Enzyme activity is maximum during the early morning.

Correct : A. True

40. Intermediate of aromatic hydroxylation is

Correct : B. Epoxide

41. Oxidation of Propranolol results in

Correct : C. 4-hydroxy propranolol

42. Oxidation of olefin results in

Correct : C. Diol

43. Oxidation of Tolbutamide is the example of

Correct : C. Oxidation of Benzylic carbon

44. Carbon atom adjacent to olefinic double bond is known as

Correct : D. Allylic carbon

45. Oxidation of Hexobarbital results in

Correct : B. 3-hydroxy Hexobarbital

46. Given reaction is the example of_________

Correct : A. Oxidation of Carbon atom alpha to Carbonyl and Imine

47. ω – oxidation of Valproic acid results in

Correct : D. 5-hydroxy valproic acid

48. ω1 – oxidation of Valproic acid results in

Correct : C. 4-hydroxy valproic acid

49. Given reaction is the example of_________

Correct : A. Oxidation of Alicyclic carbon

50. Desulphuration of given drug results in _______

Correct : A. Phenobarbitone

51. Reduction of given drug results in______

Correct : D. 7 – aminometabolite

52. Given reaction is the example of ________

Correct : C. Hydrolysis

53. By Glycine conjugation Benzoic acid results in

Correct : C. Hippuric acid

54. The enzymes are divided into two categories, these are _______ and ______

Correct : C. Microsomal and non-microsomal