2. When coulter-counter apparatus is employed for powder analysis, the following criterion is important:
Correct : B. dispersion medium should be conducting
3. In coulter-counter, as the particles travel through the orifice, the event that occurs is:
Correct : C. resistance between the electrodes increases
4. Fisher subsieve sizer is used to determine the surface area of the powder. The surface area is
measured based on the change in:
Correct : D. weight of powder when air is passed through the powdered pack
5. High repose angle of the granules indicated:
Correct : C. roughness of the granule surface
6. The true density of talc is 2.7 g/cc, the bulk density (g/cc) of talc will be:
Correct : C. less than 2.7
7. The angle of repose values are utilized to:
Correct : A. measure the movement of granules from hopper to the table of tabletting/capsule machine
8. The term ‘light’ as applied to pharmaceutical powders means:
Correct : B. low granule density
9. The type of particle diameter that is obtained by microscope method of evaluation is:
Correct : A. projected
10. Porosity of a porous powder is defined as:
Correct : B. void volume/bulk volume
11. Which equation is used to convert number distribution to weight distribution
Correct : B. Hatch Choate equation
12. Coulter counter is used to determine
Correct : A. Particle volume
13. The ratio of void volume to bulk volume is known as
Correct : A. Bulk density
14. If Carr's compressibility index value is in between 26 to 31, then flow will be
Correct : A. Poor
15. Hausner Ratio is
Correct : A. Tapped density / Bulk density
16. The powder having low bulk density or large bulk volume is known as
Correct : A. Light powder
17. The term Micromeritics was given by
Correct : A. J.M. Dalla Valle
18. Andreasen pipette is widely used method to determine particle size distribution by
Correct : B. sedimentation method
19. Porosity is expressed in
Correct : A. Percentage
20. Helium Pycnometer is used to determine
Correct : B. True density
21. The porosity of powder is equal to
Correct : A. Ratio of void volume to bulk volume.
22. The distance between two tangents on opposite sides of the particle parallel to some fixed direction.
Correct : A. Feret's diameter
23. Andreason apparatus consist of
Correct : B. Pipette
24. The physical, chemical, and pharmacologic properties of a drug are directly affected by……
Correct : C. Both of the above
25. ............is the science and technology of small particles.
Correct : A. Micromeritics
26. The unit of particle size used is in…………
Correct : D. Micrometer (µm)
27. 1 micrometer (µm) is equal to
Correct : B. 10-6 m
28. Particle size with diameter of 0.5-1.0 Micrometers (µm) is useful for……..
Correct : C. Both of the above
29. The size of a sphere is freely stated in terms of its.............
Correct : B. Diameter
30. …...is the diameter of a sphere having, the same observed area as the particle when viewed normal to
its most stable plane.
Correct : B. The projected diameter (dp)
31. .... is the number of particles per unit weight.
Correct : B. Particle number
32. …....technique is utilized for estimation of surface diameter ds.
Correct : A. Air permeability
33. The ratio of the void volume to the bulk volume of the packing is called as the....................
Correct : D. Porosity
34. In the photochemical degradation of multisulpha preparation, the order that the reaction follows is:
Correct : D. zero
35. The integral rate equation for a reaction (in common notation) is written as log C = log Co - (kt/2.303).
When a graph is drawn log c vs. t, the slope will be:
Correct : A. negative
36. The integral equation (in common notation) k = x/at (a - x) is concerned with the order:
Correct : C. second
37. When a series of steps are involved in a reaction, the ‘overall rate’ of a reaction depends upon the
rate(s) of:
Correct : C. all steps which precede the slowest step
38. The solid state decomposition of aspirin in presence of moisture follows the order:
Correct : D. zero
39. The reaction rate constant (k) is 2.0 x 10-3 min.-1 for aspirin hydrolysis in 0.1 N hydrochloric acid at
1mg/ml concentration. Under same conditions, if the product contains aspirin 4 mg/ml of the initial concentration, the k value in minutes-1 will be:
Correct : B. 2.0 x 10-3
40. A second order reaction follows pseudo-first order reaction, when the concentrations of:
Correct : C. one reactant is far higher than the other reactant.
41. In the study of the rate of a reaction, 100 ml of 0.1 N hydrochloric acid is added to 10 ml methyl
acetate for the reaction to occur. The reason for making such a proportion is to make:
Correct : D. reaction to undergo a pseudo first order
42. The conversion of trans-stilbene to cis-stilbene follows the molecularity:
Correct : C. unimolecular
43. In the hydrolysis of sucrose in hydrochloric acid solution, the change in the optical rotation follows
the order:
Correct : A. pseudofirst
44. In the degradation studies of aspirin suspension, the orders observed initially and at the end,
respectively, are: -
Correct : D. zero, first
45. A prescription of liquid aspirin preparation contained 6.5 g/100 ml. The solubility of aspirin at 25°C
is 0.33 g/100 ml. The order of reaction in the kinetic study is:
Correct : B. apparent zero
46. The time required for the complete degradation of a drug in solution is a finite value. The order of
that reaction is:
Correct : D. zero
47. Normally, ethyl acetate undergoes hydrolysis in presence of H+
and (OH)-ions. The order of the reaction observed in the acidic and alkaline solutions, respectively, are:
Correct : B. pseudo first and second
48. In reactions that follow first order kinetics, half life is expressed by equation:
Correct : A. 0.693/k1
49. The units for the specific rate constant for a second order reaction are:
Correct : A. liter/moles.sec
50. The half life of a first order reaction is 4 years. What is its shelf life (in years)?
Correct : D. 0.61
51. Which one of the following dosage forms exhibit faster rate of reaction under normal conditions?
Correct : C. solutions
52. In chemical kinetics, the rate of a reaction is expressed as (-dc/dt), where dc refers to the
concentration. Whose concentration does it refer to?
Correct : C. reactant
53. Which one of the following can be designated as the molecularity of a reaction?
Correct : B. one
54. Which one of them is refered as a general rate equation (-dc/dt) for a second order?
Correct : B. A1B1
55. Which-one of the following orders have abundant applications in biological processes?
Correct : A. first
56. In a chemical reaction, the rate constant is independent of the initial concentration. Which one of
them is the order?
Correct : D. zero
57. Chemical kinetics is the study of the
Correct : A. rate of chemical reactions
58. Rate of reaction is the
Correct : D. speed at which chemical reaction takes place
59. When rate is independent of the reactant concentration, then it is called
Correct : A. zero order reaction.
60. In the equation, Rate = k[C]c[D]d, the order of the above reaction is
Correct : D. c + d
61. Which of the following is the half life of zero order reaction
Correct : A. t1/2 = Ao/2k
62. The unit of k for zero order reaction is
Correct : A. moles/litre/second
63. Which of the following is the half life of first order reaction
Correct : D. t1/2 = 0.693/k
64. The unit of rate constant for second order reaction is
Correct : D. litre.mole-1 sec-1
65. Which of the following method/s used for determination of order of reaction?
Correct : D. All of the above -
66. The value of t1/2 for second order reaction is
Correct : A. 1/ak
67. The accelerated stability studies are primarily used to determine:
Correct : D. shelf life of the product
68. The specific rate constant (k) determined for aspirin hydrolysis in pH 1.0 buffer at 1 mg/ml
concentration is 2.0x10-3 min-1 at 25°C. The shelf life of the product is (in minutes):
Correct : B. 52
69. In general, reaction rate constants in neutral pH are comparatively:
Correct : C. lower
70. The expiry date for a tablet is not mentioned on the label. It means that the expiry time in years is:
Correct : A. five years
71. Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of decomposition of penicillin
G will be:
Correct : B. reduced
72. According to International Pharmaceutical Federation, the recommended overages be limited to the
maximum percent of:
Correct : C. thirty
73. Usually, the rate of a chemical reaction may be enhanced by:
Correct : C. raising the temperature of the reaction mixture
74. Which of the following expression is correct for the determination of shelf life for a first order
decomposition?
Correct : D. t90 = 0.105/k
75. Regarding the influence of the solvent on the rate of reaction, solvents having the internal pressure:
Correct : A. HIGHER produce products with HIGHER internal pressure
76. During autoclaving of dextrose solution, a straw colour is observed. It is due to the presence of a
substance called:
Correct : B. 5-hydroxymethylfurfural
77. In injections, procaine undergoes the degradation reactions in the following sequence:
Correct : B. hydrolysis and decarboxylation
78. On a product, the label states ‘protect from light’. What type of decomposition does the product
undergo?
Correct : D. oxidation
79. Which of the following reactions is observed in the degradation of ampicillin?
Correct : B. hydrolysis
80. Aspirin undergoes decomposition in a formulation. It can be prevented by:
Correct : D. suppressing its solubility
81. Which one of the following is primarily NOT a chemical decomposition?
Correct : D. volatilization
82. For the validity of accelerated stability studies of solution dosage form, the energy of activation
should be in the range of (in units of kcal/mole).
Correct : B. 11 to 30
83. Which one of these methods is the MOST effective in preventing the rate of hydrolysis?
Correct : C. removal of water
84. During storage, crystal growth is observed in a suspension due to:
Correct : B. fluctuations in the ambient temperatures
85. The storage directions on a parenteral solution specify ‘store in a cool place’. This may be stored in:
Correct : B. a refrigerator at 15°C
86. which of the following is cause of physical degradation of drug?
Correct : D. All of the above
87. Which of the following factors affect the rate of reaction?
Correct : D. All of the above
88. The effect of temperature on rate of reaction is explained by
Correct : A. Arrhenius equation
89. The unit of activation energy is
Correct : A. kJ/mol
90. The dielectric constant is used to measure
Correct : B. polarity of the solvent
91. Accelerated stability testing is done to
Correct : A. predict shelf of the formulation
92. ICH stands for
Correct : B. International Conference On Harmonisation
93. Stability Data for Climatic zone III & IV comes under___________ICH guideline
Correct : C. Q1F
94. Climatic zone II is
Correct : B. Subtropical and Mediterranean climate
95. Stability testing is done
Correct : D. All of the above
96. ........... is the time necessary for the concentration of the reactant to decrease to 90% of its original
concentration.
Correct : B. Shelf life
97. Generally, Stability testing is employed for...........
Correct : D. All of the above
98. A zero-order reaction is a reaction having rate of concentration of reactant.
Correct : C. Independent
99. In a second-order reaction, the sum of the exponents in the rate law is equal to...............
Correct : C. Two
100. ..........technique is utilized only during determination of order of reaction, when the rate law involved
by only single concentration term.