2. First hormone epinephrine was synthesized in Year
Correct : B. 1904
3. Who is founder of modem medicine?
Correct : A. Hippocartes
4. Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead)
is known as
Correct : A. Drug discovery
5. The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as
Correct : B. Drug development
6. Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as
Correct : A. Hit
7. Compound with good activity and selectivity in screening during drug discovery is
known as
Correct : B. Lead
8. The main goals of pre-clinical studies
Correct : C. A and B both
9. IND stands for
Correct : B. Investigational new drug
10. Human micro dosing studies conducted in which clinical phase ?
Correct : A. Phase 0
11. MTD is
Correct : D. Maximum tolerated dose
12. Single ascending dose studies are done in_____
Correct : B. Phase Ia
13. NDA is
Correct : A. New Drug Application
14. Phase IV trial is also known
Correct : C. Post marketing Surveillance
15. How many people will be selected for phase I trial?
Correct : D. 20-50 people
16. How many people will be selected for phase II trial?
Correct : C. 20-300 people
17. How many people will be selected for phase III trial?
Correct : B. 300-3000 people
18. Which one of the following will be checked under phase IV surveillance?
Correct : A. The whole market will be under surveillance
19. Precision Medicine is an emerging approach depending on
Correct : A. Genomic study of individual
20. How many main families of GPCRs are there?
Correct : B. 6
21. Which of the following reactions is catalyzed by the enzyme adenylate cyclase?
Correct : A. Conversion of ATP to cyclic AMP
22. Oxadiazole ring contains
Correct : D. 2 Nitrogen/Oxygen
23. The hetroaromatic redical is called
Correct : B. Naphthyl
24. Name of this aromatic ring is
Correct : C. 1-ethyl-2-methyl naphthalene
25. Name of this aromatic ring is
Correct : C. Azepane
26. Which of the following statements best describes pharmacodynamics?
Correct : C. The study of how a drug interacts with its target binding site at the molecular level.
27. Which of the following statements best describes pharmacokinetics?
Correct : A. The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors.
28. What are soft drugs?
Correct : B. Chemical drugs which are already found in the body
29. The most important physicochemical properties affecting drug action
a) Partition coefficient
b) Solubility
c) Acid base properties
d) Chemical bonding
e) Chelation
f) Surface activity
Correct : A. All of the above
30. In QSAR, study of medicinal chemistry Q stands for
Correct : B. Quantitative
31. Dimercaprol is a chelating agent used in the treatment of
Correct : A. Arsenic poisoning
32. The non-polar compound dispersed
Correct : B. By interacting with lipid
33. pka is a parameter which indicates the
Correct : D. All of the above
34. 85% of drugs are ionizied in which pH-
Correct : C. 1.5-8
35. Bioisoterism is the process of
Correct : B. Replacement similar valence group
36. A drug like phenytoin & barbiturate when pka is larger than 7 is
Correct : D. Unionised at pH 6
37. A drug where pka is 7 & unionised at all pH it is
Correct : B. Very weak acidic
38. Dissolution & pka helps in drug
Correct : C. Dissociation & solubility
39. Bioisosteres are similar in their
Correct : C. Both character a & b
40. Which of the following is not a bivalent?
Correct : D. SH
41. A molecule having 3 chiral centre carbon it has
Correct : B. 9 set of enantiomers
42. The 3D structure elucidation is done by process
Correct : C. NMR
43. Which of the following is odd one regarding drug-receptor interaction
Correct : D. Dipole- induced dipole interaction
44. Which of the following is a fastest receptor
Correct : C. GPCR
45. Which of the following is not an optically isomer
Correct : A. Enantiomers
46. Enantiomer has a higher affinity to receptor are called
Correct : A. Eudismic
47. Which type of hydrogen bonding present when hydrogen bonding occurs between molecules?
Correct : B. Intermolecular
48. Which compound is capable of forming a ring structure with metal atoms?
Correct : B. Chelates
49. For dissolution of solute in solvent which condition is necessary?
1. Solute-solvent interaction should be less than solute-solute and solvent-solvent interaction
2. Solute-solvent interaction should equal solute-solute and solvent-solvent interaction
3. Solute-solvent interaction should exceed solute-solute and solvent-solvent interaction
Correct : B. 2 & 3
50. Addition of polar group in a drug increases its interaction with
Correct : A. Water
51. Methyl Prednisolone is water insoluble but its which salt is water soluble?
Correct : A. Sodium
52. Phenobarbitone is water insoluble but its which salt is water soluble?
Correct : A. Sodium
53. Which ester of Chloramphenicol is prepared to mask its bitter taste?
Correct : D. Palmitate
54. Generally drugs are absorbed in which form?
Correct : B. In unionized form
55. Most weakly acidic drugs (pKa < 2) are absorbed from
Correct : A. Stomach
56. Most weakly basic drugs (pKa > 8) are absorbed from
Correct : B. Intestine
57. Absorption of neutral drugs (pKa 6- 8) is independent of pH.
Correct : A. True
58. Which form of barbituric acid has CNS activity?
Correct : C. 3
59. Addition of non-polar group _________ partition co-efficient
Correct : A. Improves
60. Gentamicin, streptokinase can be given
Correct : B. Parentrally
61. Distance between H-bond is
Correct : C. 2.5 – 3.2 A°
62. Angel of H-bond
Correct : C. 130 – 180 °
63. Strength of H-bond is
Correct : A. 1-7 Kcal/mol
64. p-nitrophenol contains
Correct : B. Intermolecular H-bond
65. Which one of the following factors related to protein-drug binding is not related to drugs?
Correct : D. Number of binding sites on the binding agent
66. Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
Correct : D. Inter subject variation
67. Which of the following factors for protein drug binding is a drug interaction factor?
Correct : A. Competition between drugs for the binding site
68. Only unbound or free drug is capable of being eliminated.
Correct : A. True
69. Plasma proteins bound with drugs by formation of
Correct : D. All
70. The most significant protein involved in binding with a drug is
Correct : A. Albumin
71. The most abundant plasma protein is
Correct : A. Albumin (HAS – Human serum albumin)
72. Chelating agent Dimercaprol is used in the treatment of
Correct : C. Arsenic poisoning
73. In Lead and vanadium poisoning, which chelating agent is used as an antidote?
Correct : A. Disodium EDTA
74. Absorption of Tetracycline is reduced in the presence of milk because of
Correct : D. Chelation
75. Functional groups of same valance and ring equivalents are known as
Correct : A. Classical Bioisosteres
76. Bioisosteres have
Correct : D. All of above
77. R (-) Epinephrine shows 3 point of interaction with receptor while S (+)Epinephrine
shows 2 point of interaction with receptor.
Correct : A. True
78. (+) Warfarin is _____times more potent than (-) Warfarin.
Correct : D. 5
79. (+) Sotalol is beta blocker while (-) Sotalol is
Correct : D. Antiarrhythmic
80. D-Penicillamine is antiarthritic while L-Penicillamine is
Correct : D. Toxic
81. D-Asparagine has sweet taste while L-Asparagine has
Correct : D. Tasteless
82. Biotransformation of drugs is defined as the conversion from one physical form to
another.
Correct : B. False
83. The drug biotransformation is a detoxification process.
Correct : A. True
84. Phase 1 reactions are also known as a synthetic reaction.
Correct : A. True
85. The phase I reactions are detoxification pathways.
Correct : A. True
86. The phase II reactions are detoxification pathways.
Correct : A. True
87. Following are the Phase I reactions except ____________
Correct : D. Sulphide reactions
88. Which of the following statements is the closest description of Phase I metabolism?
Correct : C. Reactions which add a polar functional group to a drug.
89. Which of the following statements is the closest description of Phase II metabolism?
Correct : A. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.
90. Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions?
Correct : D. Strong nonpolar groups are attached
91. Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction?
Correct : C. Glucuronyl transferase
92. Which of the following reactions is not a Phase I metabolic transformation?
Correct : B. Conjugation to alcohols
93. What is the major end product of oxidation of aromatic carbon atoms?
Correct : A. Arenols
94. Which of the following is not a common N containing functional groups which undergo
reduction reactions?
Correct : D. Nitrite compounds
95. What does the hydrolysis of Aspirin yield us with?
Correct : B. Salicylic acid and CH3COOH
96. Which enzyme is important in the Phase II reactions?
Correct : C. Transferase
97. Which of the following groups is least susceptible to cytochrome P450 enzymes?
Correct : D. Quaternary carbon atoms
98. Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved?
Correct : C. both of the above
99. Solubility of a drug in polar solvents and Non-polar solvents depends upon
Correct : D. All of above
100. Higher will be the diffusion of the drug across the membrane if
Correct : A. Higher value of partition-coefficient