1. Oral controlled release drugs release the drug only inside the intestine.
Correct : B. False
2. What are the characteristics of continuous release systems?
Correct : B. Prolonged their residence in the GIT and release
3. What is the characteristic of delayed transit and continuous release systems?
Correct : B. Prolonged their residence in the GIT and release
4. What is the characteristic of delayed release systems?
Correct : C. Release only at a specific drug
5. What is the characteristic of dissolution controlled release systems?
Correct : D. Very slow dissolution rate
6. What is the characteristic of matrix dissolution-controlled release systems?
Correct : D. Employ waxes to control the rate of dissolution
7. What is the characteristic of encapsulation or coating dissolution-controlled release systems?
Correct : A. Microencapsulation using slowly dissolving materials
8. What are the characteristics of diffusion-controlled release systems?
Correct : B. Diffusion of the dissolved drug
9. What are the characteristics of Matrix diffusion-controlled release systems?
Correct : B. Drug disperse in an insoluble matrix of rigid hydrophobic materials
10. What are the characteristics of reservoir devices-controlled release systems?
Correct : C. Hollow systems containing drug surrounded by a polymer membrane
11. What are the characteristics of ion exchange resin drug complexes?
Correct : D. Formation of complexes between the drug and anion/cation exchange resins
12. What is the characteristic of pH-independent formulations?
Correct : A. Buffering agents that adjust pH to the desired value
13. What are the characteristics of osmotic pressure-controlled systems?
Correct : B. Releases the drug at a zero-order kinetics
14. Osmotic pressure controlled systems work on the principle of osmotic pressure releasing the drug at constant 1st order kinetics.
Correct : B. False
15. What are the characteristics of hydrodynamic pressure controlled systems?
Correct : C. Generated by swelling hydrophilic hum
16. What is the characteristics of altered density systems?
Correct : D. Use of high or low density pellets
17. What is the characteristics of floating or buoyant capsule systems?
Correct : B. Granule drug with hydro gel
18. What is the characteristics of mucoadhesive systems?
Correct : C. Usage of bio adhesive polymer
19. Enteric coating are used for which systems?
Correct : A. Intestinal release systems
20. Drugs cannot be delivered to the colon.
Correct : B. False
21. What is the characteristics of intestinal release systems?
Correct : D. Use of enteric coating
22. What is the characteristics of colonic release systems?
Correct : C. Usage of polymers that dissolves only in the alkaline pH of colon
23. Liposomes are spherical structures, usually between in diameter:
Correct : D. 15nm-1000nm
24. Liposomes consists of a bilayer of
Correct : C. Both a and b
25. Liposomes have half life
Correct : B. Shorter
26. Liposomes have solubility
Correct : A. Lower
27. Liposome phospholipids undergoes
Correct : D. Both a and b
28. The diameter of Small unilamellar vesicles is
Correct : A. 20-100nm
29. Intermediate sized unilamellar vesicles are prepared by
Correct : D. Both b and c
30. Tranfersome belongs to the classification according to
Correct : C. Function
31. Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”
Correct : A. Lower
32. Loading of the entrapped agents before/during the manufacture procedure is known as
Correct : B. Passive loading
33. Passive Loading Technique includes
Correct : C. Solvent dispersion
34. Drawback of Lipid hydration method is
Correct : A. Low internal volume
35. Tip of sonicator is directly engrossed into liposome dispersion in
Correct : B. Probe sonication
36. The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs
Correct : C. Larger
37. To produce a microemulsion of small vesicles at least _______ circulations are required
Correct : A. at least 20 circulation but not greater than 200
38. Dried reconstituted vesicles method is performed in
Correct : B. Mechanical dispersion
39. Solvent vaporization is also known as
Correct : A. Ether injection
40. Amphotericin B liposomes are given
Correct : B. Oral
41. Ketoconazole liposomes are given by
Correct : C. Transdermal
42. Temperature used for Ether Injection method is______ or under reduced pressure
Correct : B. 55-65 0C
43. Which of the following drugs cannot be given as transdermal administration?
Correct : D. Drugs against peptic ulcer
44. Which of the following characteristics is suitable for transdermal drug?
Correct : C. Drugs with narrow therapeutic indices
45. What are the characteristics of the monolithic devices?
Correct : A. The drug has a large therapeutic index
46. The rate at which monolithic devices transfer drugs to the patient body is proportional to _______________ of time
Correct : B. The square root of time
47. What are the characteristics of the reservoir or membrane devices?
Correct : B. Drug permeation rate is high
48. What are the characteristics of the mixed monolithic-reservoir devices?
Correct : C. The drug-polymer matrix is layered by rate-controlling membrane
49. The absorption of the ophthalmic drug does not depend on which of the following?
Correct : D. Size of the eyeball
50. Which of the following is false in regarding reservoir devices?
Correct : D. The drug is contained in a powder form floating on liquid
51. Which of the following is true for monolithic devices?
Correct : C. Suitable for drugs with large therapeutic indices
52. The duration of action of parental controlled release systems can be extended up to what time?
Correct : D. Day, week, month even a year
53. What is the drawback of parental controlled release systems?
Correct : B. The drug cannot be easily removed once administered
54. Which one of the following should not be a characteristic of the vehicles or polymers which are used
for parenteral formulations?
Correct : B. Consists of pyrogen
55. With aqueous solutions, the drug releases can be controlled. Which of the following is not the right
method of controlling?
Correct : D. Increasing the pH to make it highly basic
56. Release of water-soluble drugs can be retarded by presenting it as ____________ suspension
Correct : A. Oil
57. Larger particle size leads to ____________ dissolution
Correct : A. Slower
58. Which of the following is a characteristic of microspheres?
Correct : A. Free flowing powders
59. Which of the following is a characteristic of oil solutions?
Correct : C. Control drug release by partitioning the drug from the oil
60. Which of the following is a characteristic of aqueous solutions?
Correct : B. Drug release can be increased by increasing viscosity
61. Which of the following is a characteristic of nanoparticles?
Correct : D. Size range 10-100 nm
62. Which of the following is a characteristic of the parental controlled drug release system by
liposomes?
Correct : C. Lipid bilayer enclosing the drug
63. Which of the following can be incorporated into a liposome?
Correct : D. Drugs, peptides, viruses, bacteria
64. Which of the following is a characteristic of resealed erythrocytes?
Correct : A. Nonimmunogenic
65. Which of the following statement is false for osmotic pumps?
Correct : C. The drug is contained a permeable polyester bag
66. Which of the following statement is true for osmotic pumps?
Correct : A. The tube is made up of stainless steel
67. Which of the following should not be a property of implants?
Correct : D. Nonremovable
68. Which is the disadvantage for implants?
Correct : D. Need of microsurgery
69. Subcutaneous tissue is an ideal location for implants?
Correct : A. True
70. Which of the following drugs are used in implants?
Correct : D. Morphine antagonist
71. Which of the following is a false statement for vapour pressure pump?
Correct : C. Drug solution chamber is separated by rigid walls
72. After implantation of a vapour pressure pump, the body has to get heated by exercising so that the
volatile liquid vaporizes.
Correct : B. False
73. Which of the following is a characteristic of battery powered pumps?
Correct : B. The system is programmed to release drugs at a controlled rate
74. The drug loading in resealed erythrocytes can be done by 1st immersing the cells in a buffered
hypertonic solution.
Correct : B. False
75. How are MLV liposomes made?
Correct : B. Series of concentric bilayers of lipid
76. How are OLV liposomes made?
Correct : A. 2-10 bilayers of lipid
77. The concentration of drug in plasma above which toxic effects are precipitated is known as
Correct : A. Maximum safe concentration
78. When rate is independent of the reactant concentration, then it is called
Correct : A. zero order reaction
79. Which of the following is the half life of zero order reaction?
Correct : A. t1/2 = A0 /2k
80. The unit of k for zero order reaction is
Correct : A. moles/litre/second
81. Which of the following is the half life of first order reaction?
Correct : D. tl/2 = 0.693 / k
82. Which of the following is not a pharmacokinetic parameters that describe the plasma level time curve?
Correct : D. Minimum Effective Concentration
83. The drug concentration between Minimum Effective Concentration and Maximum Safe Concentration
is called
Correct : A. Therapeutic range
84. tmax indicates
Correct : A. drug absorption rate
85. What Will be the approximate Tmax of a drug exhibiting Ka of 2 hr-1 and K of 0.2 hr-1 ?
Correct : A. 1.2 hr
86. A drug solution has half life of 21 days. Assuming that drug undergoes first order kinetics, how long
will it take for the potency to drop to 90% of initial potency?
Correct : A. 3.2 days
87. A suspension shows zero-order kinetic with a rate constant 2mg/ml.month. The dose of suspension is
20mg/ml. The biological half life of the above dosage form is
Correct : A. 5 months
88. Drug showing zero order kinetic of elimination
Correct : B. Show plot of drug concentration vs time (linear Plot)
89. Elimination after 4 half lives in first order kinetics is
Correct : B. 93%
90. Which one is irrational statement for first order kinetics?
Correct : D. All of these
91. T % (Half life time) of a drug can determine all of the following except
Correct : B. Therapeutic dose
92. The area under serum concentration time curve of drug represents
Correct : D. The amount of drug excreted in urine
93. Under non compartment analysis the following formula is used for calculation
Correct : A. MRT = AUMC / AUC
94. Under compartment modeling, Wegner-Nelson-Method involves
Correct : A. Determination of absorption rate constant (Ka) from %ARA Vs time curve
95. The steady-state concentration of a drug can be double by:
Correct : B. Doubling the rate of infusion only.
96. In compartment modeling the term "Open" indicates
Correct : A. Unidirectional input and output
97. Select the formula to calculate steady state concentration follows IV infusion
Correct : A. Css= Infusion Rate/ Clearance
98. IV infusion model follows
Correct : A. Zero order absorption and first order elimination kinetic
99. Select the formula to calculate elimination half life
Correct : B. t1/2 = 0.693 / Ke
100. The constants that represent reversible transfer of drug between compartments are called as