Quiznetik

Current Advances of Novel Drug Delivery System | Set 1

1. Liposomes are spherical structures, usually between in diameter……………..

A. 80nm-100nm

B. 60nm-100nm

C. 55nm-1000nm

D. 15nm-1000nm

Correct : D. 15nm-1000nm

2. Liposomes consists of a bilayer of…………………

A. Hydrophilic molecules

B. Hydrophobic molecules

C. Both a and b

D. None

Correct : C. Both a and b

3. Liposomes have half-life …………….

A. Longer

B. Shorter

C. Intermediate

D. Both a and b

Correct : B. Shorter

4. Liposome phospholipids undergoes ………………

A. Oxidation

B. Hydrolysis

C. Acetylation

D. Both a and b

Correct : B. Hydrolysis

5. Intermediate sized unilamellar vesicles are prepared by

A. Sonication

B. High pressure extrusion technique

C. Detergent dialysis

D. Both b and c

Correct : D. Both b and c

6. The diameter of Small unilamellar vesicles is

A. 20-100nm

B. 20-1000nm

C. 10-100nm

D. 100nm-400nm

Correct : A. 20-100nm

7. Tranfersome belongs to the classification according to

A. Composition

B. Application

C. Function

D. None of the above

Correct : C. Function

8. Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”.

A. Lower

B. Higher

C. Single

D. None of the above

Correct : A. Lower

9. Passive Loading Technique includes…………..

A. Lyophilization

B. Proliposomes

C. Solvent dispersion

D. Both a and b

Correct : C. Solvent dispersion

10. Loading of the entrapped agents before/during the manufacture procedure is known as…………

A. Active loading

B. Passive loading

C. Both a and b

D. None of the above

Correct : B. Passive loading

11. Drawback of Lipid hydration method is

A. Low internal volume

B. High encapsulation efficiency

C. Size distribution is homogenous

D. None of the above

Correct : A. Low internal volume

12. Tip of sonicator is directly engrossed into liposome dispersion in……………

A. Bath sonication

B. Probe sonication

C. None of the above

D. all

Correct : B. Probe sonication

13. The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs.

A. Smaller

B. Equal

C. Larger

D. all

Correct : C. Larger

14. To produce a microemulsion of small vesicles at least _______ circulations are required

A. at least 20 circulation but not greater than 200

B. 10 circulations

C. at least 200 circulation but not greater than 2000

D. at least 2 circulations but not greater than 10

Correct : A. at least 20 circulation but not greater than 200

15. Dried reconstituted vesicles method is performed in…………..

A. Solvent dispersion

B. Mechanical dispersion

C. Both a and b

D. none

Correct : B. Mechanical dispersion

16. Solvent vaporization is also known as………………….

A. Ether injection

B. Ethanol injection

C. Double emulsification

D. Reverse-phase evaporation

Correct : A. Ether injection

17. Temperature used for Ether Injection method is______ or under reduced pressure.

A. 15-25 ̊C

B. 55-65 ̊C

C. 55-85 ̊C

D. None of the above

Correct : B. 55-65 ̊C

18. Ketoconazole liposomes are given by…………….

A. Lungs

B. Oral

C. Transdermal

D. Intravenous

Correct : C. Transdermal

19. Amphotericin B liposomes are given……………..

A. Lungs

B. Oral

C. Transdermal

D. Intravenous

Correct : B. Oral

20. In niosomes phospholipids are ………………

A. Present

B. Absent

C. Both a or b

D. None

Correct : A. Present

21. Pharmacosome belongs to the classification according to

A. Composition

B. Function

C. Application

D. None of the above

Correct : B. Function

22. Which of the following can be incorporated into a liposome?

A. Only drugs and viruses

B. Only Peptides and viruses due to similar characteristics

C. Only viruses

D. Drugs, peptides, viruses, bacteria

Correct : D. Drugs, peptides, viruses, bacteria

23. How are MLV liposomes made?

A. 2-10 bilayers of lipid

B. Series of concentric bilayers of lipid

C. The single bilayer of lipid

D. 100 bilayer of lipid

Correct : B. Series of concentric bilayers of lipid

24. How are OLV liposomes made?

A. 2-10 bilayers of lipid

B. Series of concentric bilayers of lipid

C. A single bilayer of lipid

D. 100 bilayer of lipid

Correct : A. 2-10 bilayers of lipid

25. Which of the following is a characteristic of the parental controlled drug release system by liposomes?

A. Free flowing powders

B. Aqueous solutions

C. Lipid bilayer enclosing the drug

D. Administration of emulsions

Correct : C. Lipid bilayer enclosing the drug

26. Which of the following drugs can not be given as transdermal administration?

A. Drugs with very short half life

B. Drugs with narrow therapeutic index

C. Easy removal and termination

D. Drug against peptic ulcer

Correct : D. Drug against peptic ulcer

27. What are the characteristics of the monolithic devices?

A. The drug has a large therapeutic index

B. Aqueous solution

C. Control drug release by partitioning the drug from oil

D. Administration of emulsion

Correct : A. The drug has a large therapeutic index

28. Which of the following characteristics is suitable for transdermal drug?

A. Large drug dose

B. Large molecular size

C. Drugs with narrow therapeutic index

D. Drug which are metabolized in the skin

Correct : C. Drugs with narrow therapeutic index

29. The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.

A. Square of time

B. The square root of time

C. Twice the time

D. Half the time

Correct : B. The square root of time

30. What are the characteristics of the reservoir or membrane devices?

A. The drug has a large therapeutic index

B. Drug permeation rate is high

C. Control drug release by partitioning the drug from oil

D. Administration of emulsion

Correct : B. Drug permeation rate is high

31. What are the characteristics of the mixed monolithic reservoir devices?

A. The drug has a large therapeutic index

B. Drug permeation rate is high

C. The drug polymer matrix is layered by rate controlling membrane

D. Administration of emulsion

Correct : C. The drug polymer matrix is layered by rate controlling membrane

32. Which of the following is false in regarding reservoir devices?

A. These devices are used when the drug permeation rate is rapid

B. The release of the drug is controlled

C. Suitable for low therapeutic index

D. The drug is contained in a powder from floating on liquid

Correct : D. The drug is contained in a powder from floating on liquid

33. Which of the following is true for monolithic devices?

A. These devices are used when the drug permeation rate is rapid

B. The release of the drug is controlled

C. Suitable for drugs with large therapeutic index

D. The drug is contained in a powder form floating on liquid

Correct : C. Suitable for drugs with large therapeutic index

34. The absorption of the ophthalmic drug does not depend on which of the following?

A. Physicochemical properties of permeating molecule

B. Drainage of tears

C. Output of tears

D. Size of the eyeball

Correct : D. Size of the eyeball

35. Which of the following is false for monolithic devices?

A. The drug used for these devices has large therapeutic index

B. There are three categories of matrix devices

C. 1st type has the drug dissolved in the polymer matrix

D. 2nd type has drug delivery

Correct : B. There are three categories of matrix devices

36. Problems with opioid TDDS include.

A. Poor patient compliance

B. Allergy

C. Constipation.

D. Respiratory depression.

Correct : B. Allergy

37. Regarding the skin:

A. The epidermis is the thickest layer.

B. The stratum corneum is the greatest barrier to transdermal transport.

C. The dermis has a rich capillary blood supply.

D. Skin hydration is a cause of inter-individual variation in drug absorption.

Correct : D. Skin hydration is a cause of inter-individual variation in drug absorption.

38. How much thickness of the dermis layer?

A. 2 to 7 nm

B. 3 to 5 nm

C. 3 to 6 nm

D. 5 to 8 nm

Correct : B. 3 to 5 nm

39. TDDS is usually only suitable for drugs of what level of potency?

A. Typically only for drugs of high potency.

B. Low potency

C. High to low potency

D. Low to high potency

Correct : A. Typically only for drugs of high potency.

40. In the use of TDDS for drug application ? size has to be considered reasonable?

A. Strip size

B. Patch size

C. Film size

D. Diskette size

Correct : B. Patch size

41. What is the largest organ of the body?

A. Liver

B. Lungs

C. Skin

D. Brain

Correct : C. Skin

42. Which of the following is false for Merits of the TDDS.

A. Avoidance of the First pass effect

B. A stable and controlled blood level

C. Termination at any time is conceivable

D. Skin irritation and allergic response

Correct : D. Skin irritation and allergic response

43. How many layer are seen in monolithic TDDS design?

A. 4

B. 3

C. 5

D. 2

Correct : B. 3

44. How many layer are seen in membrane-controlled system?

A. 3

B. 5

C. 4

D. 6

Correct : C. 4

45. A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.

A. Iontophoresis

B. Sonophoresis

C. Electrophoresis

D. Ion exchange

Correct : A. Iontophoresis

46. A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.

A. Iontophoresis

B. Sonophoresis

C. Electrophoresis

D. Ion exchange

Correct : B. Sonophoresis

47. Which component are not included in combination of the SEDDS formulation?

A. Oil

B. Lipid

C. Drug

D. Wax

Correct : D. Wax

48. SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.

A. GIT

B. RT

C. UT

D. Liver

Correct : A. GIT

49. SEDDSs produce emulsion with droplet size between ____________.

A. 200 to 400nm

B. 100 to 300nm

C. 10 to 100nm

D. 1000nm

Correct : B. 100 to 300nm

50. Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.

A. 50 nm

B. 70 nm

C. 100 nm

D. 200 nm

Correct : A. 50 nm

51. Which sentence is false in the merits of SEDDS?

A. Quick onset of action

B. Increase the Drug Dose.

C. Ease of manufacture & Scale up.

D. Improvement in oral bioavailability.

Correct : B. Increase the Drug Dose.

52. Which one more convenient route of administration for SEDDS.

A. Oral

B. I.V

C. I.M

D. Skin

Correct : A. Oral

53. Which of the following false for in example of oil in SEDDS?

A. Corn oil

B. Olive oil

C. Sesame oil

D. Rice oil

Correct : D. Rice oil

54. Which of the following is false for in examples of Surfactant in SEDDS?

A. Polysorbate 20

B. Polysorbate 80

C. Span 20

D. Sorbitan monooleate

Correct : C. Span 20

55. Which of the following is false for example of co-solvent?

A. Chloroform

B. Ethanol

C. Glycerin

D. Propylene glycol

Correct : A. Chloroform

56. Which are not Preferable route of administration for SEDDS?

A. Oral

B. Parenteral

C. Ophthalmic

D. Intra muscular

Correct : D. Intra muscular

57. Mucoadhesive drug delivery system is a part of ___________delivery system?

A. Control

B. Sustained

C. Prolong

D. Target

Correct : A. Control

58. Drug loading capacity of MDDS.

A. Low

B. High

C. Very low

D. Medium

Correct : B. High

59. Which theory use for the attractive electrostatic forces between glycoprotein Mucin network & the bio adhesive/ mucoadhesive material?

A. Electronic theory

B. Wetting theory

C. Adsorption theory

D. Diffusion theory

Correct : A. Electronic theory

60. Which theory use for Physical entanglement of Mucin strands and flexible polymer chains.

A. Wetting theory

B. Adsorption theory

C. Diffusion theory

D. Fracture theory

Correct : C. Diffusion theory

61. Which route is not use for MDDS?

A. Nasal

B. Rectal

C. Oral

D. Buccal

Correct : C. Oral

62. Which polymers is not included in the semisynthetic class?

A. Chitosan

B. Gelatin

C. Pectin

D. Carbopol

Correct : D. Carbopol

63. Which polymers is not soluble in water?

A. PVP

B. CMC

C. PEG

D. HPMC

Correct : C. PEG

64. Which polymers are not having charge?

A. Starch

B. Amino dextran

C. Pectin

D. Sodium CMC

Correct : A. Starch

65. Which sentence is false in merits of MDDS?

A. Targeting & localization of the dosage form at a specific site

B. Painless administration

C. Low enzymatic activity & avoid of first pass metabolism

D. Some patient suffers unpleasant feeling

Correct : D. Some patient suffers unpleasant feeling

66. Which are the following not including in semisolid dosage form in MDDS?

A. Gel & ointment

B. Tablet

C. Films

D. Patches

Correct : B. Tablet

67. What is the characteristics of mucoadhesive systems?

A. Release the drug along the entire length of GIT

B. Prolonged their residence in the GIT and release

C. Usage of bio adhesive polymer

D. Use of high or low density pellets

Correct : C. Usage of bio adhesive polymer

68. Mucoadhesive are including in which drug delivery system?

A. Target drug delivery system

B. Control drug delivery system

C. Prolong drug delivery system

D. Diffusion drug delivery system

Correct : B. Control drug delivery system

69. Loading capacity of Mucoadhesive drug delivery system?

A. High

B. Poor

C. Medium

D. Very Poor

Correct : B. Poor

70. Howmany water percentage are present in Mucoadhesive drug delivery system?

A. 90 %

B. 80%

C. 95 %

D. 101%

Correct : C. 95 %

71. Howmany nontechnology based product approved for clinical use?

A. 20

B. 24

C. 30

D. 10

Correct : B. 24

72. What are the size of nanoparticles?

A. 10 – 100 nm

B. 1 – 100 nm

C. 10 – 1000 nm

D. None

Correct : B. 1 – 100 nm

73. Which of the following is a characteristic of nanoparticles?

A. Free flowing powders

B. Aqueous solutions

C. Control drug release by partitioning the drug from the oil

D. Size range 1 -100 nm

Correct : D. Size range 1 -100 nm

74. Nanoparticles are dived in ………….. class ?

A. 3

B. 2

C. 4

D. 0

Correct : B. 2

75. Which are protein is includes in natural protein ?

A. PECL

B. PLA

C. Gelatin

D. PMMA

Correct : C. Gelatin

76. Who first used the term Nanotechnology?

A. Richard Feymann

B. Norio Taniguichi

C. Eric Drexler

D. Sumio Lijima

Correct : B. Norio Taniguichi

77. How many oxygen atoms lined up in a row would fit in a one nanometer space?

A. None

B. One

C. Seven

D. Seventy

Correct : C. Seven

78. Which of these statements is NOT true?

A. Gold at the nanoscale is red

B. Copper at the nanoscale is transparent

C. Silicon at the nanoscale is an insulator

D. Aluminium at the nanoscale is highly combustible

Correct : C. Silicon at the nanoscale is an insulator

79. Which of the following is an example of top-down approach for the preparation of nanomaterials?

A. Gas phase agglomeration

B. Molecular self-assembly

C. Mechanical grinding

D. Molecular beam epitaxy

Correct : C. Mechanical grinding

80. Which of the following is an example of bottom-up approach for the preparation of nanomaterials?

A. Etching

B. Dip pen nano-lithography

C. Lithography

D. Erosion

Correct : B. Dip pen nano-lithography

81. What is the general name for the class of structures made of rolled up carbon lattices?

A. Nanorods

B. Nanotubes

C. Nanosheets

D. Fullerods

Correct : B. Nanotubes

82. What ratio decides the efficiency of nano-substances?

A. Weight/Volume

B. Surface area/Volume

C. Volume/Weight

D. Pressure/Volume

Correct : B. Surface area/Volume

83. “There is plenty of room at the bottom”. This was stated by

A. Eric Drexler

B. Harold Croto

C. Richard Feymann

D. Richard Smalley

Correct : C. Richard Feymann

84. ____________ is the field in which the nanoparticles are used with silica coated iron oxide

A. Magnetic applications

B. Electronics

C. Medical diagnosis

D. Structural and mechanical materials

Correct : C. Medical diagnosis

85. Coating the nano crystals with the ceramics is carried that leads to__________ .

A. Corrosion

B. Corrosion resistant

C. wear and tear

D. Soft

Correct : B. Corrosion resistant

86. Which of the ceramic components are easier through nano structuring?

A. Lubrication

B. Coating

C. Fabrication

D. Wear

Correct : C. Fabrication

87. How is nanotechnology used in the medical community?

A. Testing and diagnosis

B. Tissue engineering

C. Drug delivery

D. All the above

Correct : D. All the above

88. Nanoscience can be studied with the help of ___________ .

A. Quantum mechanics

B. Newtonian mechanics

C. Macro-dynamics

D. Geophysics

Correct : A. Quantum mechanics

89. The compressive strength of a nanotube ________ its tensile strength.

A. is less than

B. is greater than

C. is equal to

D. may be greater than

Correct : A. is less than

90. The nanomaterials are used in the light emitted electron luminescent devices.

A. True

B. False

C. none

D. all

Correct : A. True

91. Gel electrophoresis separates nucleic acid molecules based on ____________

A. charge on molecules

B. size of the molecules

C. nature of the molecules i.e. whether DNA or RNA

D. chemical properties of the nucleic acids

Correct : B. size of the molecules

92. Which of the following is a characteristic of microspheres?

A. Free flowing powders

B. Aqueous solutions

C. Control drug release by partitioning the drug from the oil

D. Administration of emulsions

Correct : A. Free flowing powders

93. What are the size of Microspheres ?

A. > 200 μm

B. < 200 μm

C. Both a and b

D. None

Correct : B. < 200 μm

94. What are the shape of the Microparticulates ?

A. Square

B. Triangle

C. Spherical

D. None

Correct : C. Spherical

95. Synonyms of the Microspheres………

A. Beads

B. Capsules

C. All

D. None

Correct : C. All

96. In microspheres duration of action …………

A. Fast

B. Slow

C. Moderate

D. None

Correct : A. Fast

97. Which are the not proper ideal properties of the microspheres ?

A. Longer duration of action

B. Control of content release

C. Protection of drug

D. Decrease of therapeutic efficiency

Correct : D. Decrease of therapeutic efficiency

98. Which are the example of non biodegradable synthetic polymers used in preparation of microspheres?

A. Proteins

B. Poly (acryl) dextran

C. PMMA

D. Lactides

Correct : C. PMMA

99. Which are the examples of natural material used in preparation of the microspheres?

A. Albumin

B. Gelatin

C. All

D. None

Correct : C. All

100. The charge present on the DNA backbone is negative. The force required to accelerate the molecules towards anode is directly proportional to the number of ____________

A. sugar molecules

B. nitrogenous bases

C. phosphate groups

D. both phosphate group and sugar molecules

Correct : C. phosphate groups