1. ……….. is a mathematical concept which describes a space in the body which a drug appears to
occupy.
Correct : B. Compartment
2. ………………..is the manner in which a drug is taken.
Correct : A. Dosage regimen
3. …………………it is the extent to which a drug will accumulate relative to the first dose can be
quantified by an accumulation factor R.
Correct : A. Accumulation Index
4. ………………… is an initial higher dose of a drug that may be given at the beginning of a course of
treatment before dropping down to a lower maintenance dose.
Correct : C. Loading dose
5. The compartment models provide visual representation of various rate processes involved in
drug disposition. Given statement is:
Correct : B. True
6. ...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and
uniform drug distribution.
Correct : A. Central compartment
7. ……………composed of groups of tissues with lower blood perfusion and different affinity
the drug with slow drug distribution.
Correct : B. Peripheral compartment
8. A multicompartment model assumes that all transfer rate processes for the passage of drug into or out
of individual compartments are…………….. processes.
Correct : A. First-order
9. The multicompartment models are intended to provide…………….
Correct : C. Both of the above
10. The biological half-life of drug:
Correct : C. may be increased in patients with impaired renal failure
11. The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who
have an:
Correct : B. increased volume of distribution or decreased clearance
12. Half life (t1/2) is the time required to:
Correct : A. change the amount of a drug in plasma by half during elimination
13. Half life (t1/2) does not depend on:
Correct : B. time of drug absorption
14. Elimination rate constant (Kelim) is defined by the following parameter:
Correct : D. half life (t1/2)
15. Systemic clearance (Cl) is related with:
Correct : C. volume of distribution, half life and elimination rate constant
16. Biological Half life equation for first order process is
Correct : B. t1/2 = 0.693/K
17. The area under the serum concentration time curve of the drug represents:
Correct : C. The amount of drug absorbed
18. Drug having ……..half-lives take a very short time to achieve plateau concentration.
Correct : A. shorter
19. The primary pharmacokinetic parameter clearance can be calculated by
Correct : D. all of the above
20. ………..change in drug kinetics is known as chronokinetics.
23. Concentration of drug at peak is known as …………drug concentration.
Correct : A. maximum
24. In one compartment open model, the term open indicates input and output is:
Correct : A. unidirectional
25. The mathematical relationship between plasma drug concentration and pharmacological response is
called as………..
Correct : C. PK-PD modeling
26. The ratio of maximum safe concentration to minimum effective concentration is called as
Correct : A. Therapeutic index
27. Half life of zero-order process is proportional to of drug.
Correct : A. initial concentration
28. The ability of liver to excrete drug in bile is expressed by………
Correct : B. biliary clearance
29. …………..is nothing but manner in which drug should be taken.
Correct : B. dosage regimen
30. What is dosage regimen?
Correct : C. The manner in which a drug is taken
31. What is optimal multiple dosage regimen?
Correct : B. Dosage which maintains the plasma concentration within the therapeutic window.
32. On what basis the dose interval is calculated?
Correct : B. Half-life of the drug
33. What is fluctuation?
Correct : A. Cmax/Cmin
34. How do you calculate the ideal body weight for men?
Correct : A. 50 kg +- 1kg/2.5cm above or below 150 cm in height
35. How do you calculate the ideal body weight for a woman?
Correct : B. 45 kg +- 1kg/2.5cm above or below 150 cm in height
36. Which of the following drugs are lipid soluble?
Correct : A. Phenytoin
37. Which of the following drugs get distributed to the same extent in both lean and adipose tissue?
Correct : B. Caffeine
38. Which of the following drugs can get distributed to the excess body space of obese patient?
Correct : D. Antibiotics
39. Which of the following drug can get distributed in the excess body space?
Correct : C. Digoxin
40. Neonates, infants and children require different dosages than adults.
Correct : A. True
41. Accumulation occurs because drug from previous doses was not being removed completely.
Correct : A. True
42. The renal clearance of a drug bound to plasma protein is increased after displacement with another
drug.
Correct : A. True
43. Which of the following promotes excretion of acidic drugs?
Correct : A. Citrates
44. Which of the following promotes the excretion of basic drugs?
Correct : D. Ammonium chloride
45. This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to?
Correct : B. 1-20 years
46. This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 72 * Scr formula belong to?
Correct : C. Males above 20 years
47. This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 85 * Scr formula belong to?
Correct : D. Females above 20 years
48. A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.
Correct : C. 96.25 ml/min
49. An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.
Correct : D. 174.131 ml/min
50. Which creatinine clearance value shows moderate renal failure?
Correct : B. 20-50 ml/min
51. Which creatinine clearance value shows severe renal failure?
Correct : C. Below 10 ml/min
52. Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without
renal failure.
Correct : B. False
53. Which kind of membrane is used in haemodialysis?
Correct : A. Artificial Semipermeable membrane
54. Which kind of membrane is used in haemodialysis?
Correct : C. Natural semipermeable membrane of peritoneal cavity
55. Which of the following will not be a factor governing the removal of substances through dialysis?
Correct : C. Disintegration time
56. Haemodialysis is also known as extracorporeal dialysis.
Correct : A. True
57. Which of the following is not a mechanism for pharmacokinetic analysis?
Correct : D. Human model
58. In which of the following models the body is considered to be composed of several compartments?
Correct : A. Compartment model
59. In which of the model peripheral compartments are connected to a central compartment?
Correct : D. Mammillary model
60. Which organs will make up the peripheral compartment?
Correct : D. Pancreas
61. In which model compartments are joined in series?
Correct : B. Caternary model
62. Which of the following is not a characteristic of the caternary compartment model?
Correct : C. Compartments and parameters bear a relationship with physiologic functions
63. In noncompartmental analysis, Mean residence time is equal to _____________
Correct : A. The area under the first moment curve/area under the zero moment curve
64. Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data?
Correct : C. Physiologic model
65. Which of the following will be a disadvantage for the physiologic model?
Correct : C. Obtaining experimental data for each of the organs
66. Which model is also known as membrane permeation rate limited?
Correct : A. Physiologic model
67. What does the word “open” mean in the one compartment open model?
Correct : C. Unidirectional input and output
68. How much time does an intravenously administered drug take to complete a complete circulation?
Correct : C. 1-3 min
69. In the equation log C = log Co – KEt/2.303, what does Co stand for _______
Correct : D. Plasma drug concentration immediately after i.v. injection.
70. What is meant by elimination half-life?
Correct : D. Time take for half of the amount of drug to get completely eliminated from the body as well as plasma
71. What is the equation to find out the apparent volume of distribution?
Correct : A. Amount of drug in the body/plasma drug concentration
72. The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?
Correct : C. 625 ml
73. To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?
Correct : C. 1080 mg
74. What is the equation to find out hepatic clearance?
Correct : B. Rate of elimination by kidney/plasma drug concentration
75. Which organs comprise the central compartment in a two compartment model?
Correct : D. Liver
76. Which organ comprises the peripheral compartment in a two compartment model?
Correct : D. Muscles
77. Which of the following is not a category of 2 compartment model?
Correct : D. Two compartment model with elimination from both the compartments
78. Non-linear pharmacokinetics is also known as………
Correct : D. All of the above
79. The characteristic of non-linear pharmacokinetics include…………..
Correct : C. Area under the curve is not proportional to the dose
80. Which of following drug shows non-linearity in hepatic excretion?
Correct : A. Carbamazepine
81. Pharmacokinetics parameters change as per………… of dose administered?
Correct : A. Size
82. Linear Pharmacokinetics is………………
Correct : A. Dose dependent
83. Non-linear Pharmacokinetics also called as…………
Correct : D. All of the above
84. In…………..Pharmacokinetic parameters for a drug can change with change in dose.
Correct : B. Non-linear Pharmacokinetics
85. The………………….. is common cause of both dose and time dependent kinetics
Correct : C. Enzyme induction
86. When Km << C. In this condition…………..
Correct : B. Km + C = C
87. Active processes which are Saturable in renal excretion of drug includes…….
Correct : C. Both of the above
88. Linear Pharmacokinetics also referred as………….
Correct : A. First-order kinetics
89. If the steady-state plasma concentration is directly proportional to the dose, then ……….in the
kinetics exists.
Correct : A. Linearity
90. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantified
by an accumulation factor R.
Correct : A. Accumulation Index
91. Which of the following is correct statement about Nonlinear pharmacokinetics?
Correct : C. the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
92. Which of the following Factors causing Non-linearity?
Correct : D. All of the above
93. In Michaelis-Menton Equation, When the value of Km = C
Correct : A. rate of process is half (1 /2) the maximum rate.
94. Name the different methods used to estimate Km and Vmax graphically.
Correct : D. All of the above
95. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular
drug.
Correct : A. True
96. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
Correct : D. Saturation of binding sites on plasma proteins
97. Which one of these is correct Michaelis-Menten equation?