1. Which vitamin molecules will bind to alpha 2 globulin?
Correct : C. Vitamin A, D, E, K
2. What is the molecular weight of human serum albumin?
Correct : B. 65,000 Dalton
3. HSA comes under which protein family?
Correct : B. Receptor
4. What is the name of the drug binding site I of HSA?
Correct : D. Warfarin and azapropazone binding site
5. Which one of the below does not belong to the 4 classes of lipoprotein?
Correct : D. Fatty acids
6. Which of the given drugs bind to Α1 globulin?
Correct : A. Steroidal drugs
7. What is the name of the drug binding site IV of HSA?
Correct : A. Tamoxifen binding site
8. Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein.
Correct : B. False
9. Which of the given drugs bind to Β2 globulin?
Correct : D. Carotenoids
10. What is the name of the drug binding site III of HSA?
Correct : B. Digitoxin binding site
11. Which drugs bind to RBC membrane?
Correct : C. Imipramine
12. What is the name of the drug binding site II of HSA?
Correct : C. Diazepam binding site
13. Which one of the following factors related to protein-drug binding is not related to drugs?
Correct : D. Number of binding sites on the binding agent
14. Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
Correct : D. Inter subject variation
15. Which of the following factors for protein drug binding is a drug interaction factor?
Correct : A. Competition between drugs for the binding site
16. Which drugs bind to HSA easily?
Correct : B. Anionic drug
17. Which drugs easily bind to adipose tissue?
Correct : C. Lipophilic drug
18. Which drug easily bind to AAG?
Correct : A. Cationic drug
19. The extent of drug-protein binding can change with both changes in protein and drug concentration.
Correct : A. True
20. In the equation X= Vd C, what does X stands for?
Correct : D. Amount of drug in the body
21. Only unbound or free drug is capable of being eliminated.
Correct : A. True
22. Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
Correct : A. True
23. Displacement interactions are significant in the case of drugs which are more than 95% bound.
Correct : A. True
24. Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
Correct : C. Cu/C
25. The value of association constant, Ka and the number of binding sites N can be obtained by
Correct : D. All of the above
26. Which of the following drug bind to α1 globulin?
Correct : A. Steroids
27. What is interaction of phenobarbitone and warfarin?
Correct : A. Displacement of warfarin from binding site
28. Which process involves alteration of drug distribution?
Correct : C. Both
29. Two most common protein involved in plasma protein binding are
Correct : B. Albumin and globulin
30. All of the following displace imipramine from protein binding site except
Correct : C. Ethosuximide
31. The drugs which are most affected in pregnancy are those having
Correct : B. High protein binding and low Vd
32. Most of drugs will bind with which of plasma protein
Correct : A. Albumin
33. Which of the following is not highly protein bound drug
Correct : D. Aspirin
34. Blood plasma belongs to
Correct : A. Interstitial fluid
35. Drug elimination involves....... (ADME are steps of pharmacokinetics)
Correct : C. ME
36. Filtration fraction is
Correct : C. Ration of CFR to RPF
37. Creatinine clearance is used as measurement for
Correct : A. Glomerular filtration rate
38. What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg
Correct : B. 10 hours
39. A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of
blood flow to the liver would be
Correct : D. 1500 milliliters/min
40. Which process involves alteration in drug excretion?
Correct : C. Both
41. Which of the following is not a step of renal excretion?
Correct : B. Tubular filtration
42. Renal clearance is expressed as
Correct : A. Rate of urinary excretion / Plasma drug concentration
43. Glomerular filtration rate would be increased by
Correct : D. decrease in the concentration of plasma protein
44. The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in
the urine is known as the
Correct : B. clearance of the substance
45. Nephron is functional unit of…………..
Correct : A. Kidney
46. Hepatic extraction ratio of 0.60 indicates that
Correct : A. 40% drug is left after extraction by the liver
47. First pas metabolism occurs in:
Correct : A. Liver
48. The term "biotransformation" includes the following.
Correct : B. Process of physicochemical and biochemical alteration of a drug in the body
49. For the calculation of the volume of distribution (Vd) one take into account:
Correct : B. Concentration of substance in plasma
50. Biotransformation of a medicinal substance results in:
Correct : B. Faster urinary excretion
51. Biotransformation of the drugs is to render them:
Correct : A. Less lipid soluble
52. Select the right statement.
Correct : B. Microsomal oxidation results in an increase of ionization and water solubility of a drug
53. Choose the drug type for which microsomal oxidation is the most prominent.
Correct : B. Lipid soluble
54. Metabolic transformation (phase 1) is:
Correct : A. Glucuronide formation
55. Which of the following processes proceeds in the second phase of biotransformation?
Correct : A. Acetylation
56. Conjugation is:
Correct : C. Coupling of a drug with an endogenous substrate
57. Tick the drug type for which microsomal oxidation is the most prominent:
Correct : A. Lipid soluble
58. Stimulation of liver microsomal enzymes can:
Correct : A. Require the dose increase of some drugs
59. Conjugation of a drug includes the following except:
Correct : C. Hydrolysis
60. The renal clearance of inulin is used as a measurement of
Correct : D. glomerular filtration rate
61. p-aminohippurate is used to measure
Correct : B. effective renal blood flow
62. Total body clearance is
Correct : A. the drug elimination rate divided by the plasma drug concentration
63. Renal excretion of drug depend on
Correct : D. All of above
64. For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximum
clearance is approximately
Correct : C. 120 milliliters/min
65. Elimination is expressed as follows:
Correct : D. Clearance of an organism from a xenobiotic
66. ………….drug shows active tubular secretion.
Correct : A. Penicillin
67. Which tissue has the greatest capacity to biotransform of drugs?
Correct : C. Liver
68. The process in which some drugs stimulate their own metabolism is known as
Correct : B. Autoinduction
69. Drugs undergoing first pass metabolism are advised not to be administered through
Correct : B. Oral
70. ………..is defined as volume of blood or plasma from drug is removed in unit time
Correct : A. half life
71. Tubular reabsorption is achieved by……………
Correct : C. Both (a) & (b)
72. Below mentioned all factors increases plasma elimination half life except
Correct : D. Higher ratio renal / hepatic clearance
73. Hepatic excretion of drug with high extraction ratio is altered by
Correct : B. Blood flow
74. The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as
……………
Correct : B. enzyme inhibition
75. Active tubular reabsorption of drug depends on………………
Correct : D. all of the above
76. Which of the following is not a factor of renal excretion?
Correct : C. Blood pH
77. Which of the following is not a physicochemical factor of drug that can affect the renal excretion?
Correct : B. Disintegration rate
78. Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.
Correct : B. False
79. Clearance is inversely related to volume of distribution.
Correct : A. True
80. Which drugs cannot be filtered through glomerulus?
Correct : A. Drugs bound to plasma proteins
81. Which one is the correct equation to calculate fraction of unbound drug in plasma?
Correct : A. Concentration of unbound drug in plasma / total plasma concentration of drug
82. What is total systemic clearance?
Correct : D. Sum of renal and non-renal clearances
83. What is the equation for clearance?
Correct : A. Elimination rate / plasma drug concentration
84. What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?
Correct : A. 104g/min
85. What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug
concentration is 4.2 ng/ml?
Correct : A. 148.80ml2/ng min
86. How renal clearance ratio is expressed?
Correct : C. Renal clearance of drug/ renal clearance of creatinine
87. What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance
of creatinine is 95ml/min?
Correct : A. 0.421
88. How do you calculate the rate of excretion by kidneys?
Correct : B. Rate of filtration + rate of secretion – Rate of absorption
89. What will be the rate of filtration if the rate of secretion is 0.9 ml/ sec, rate of reabsorption is 0.2 ml/sec and the rate of excretion is 2ml/sec for a particular drug?
Correct : D. 1.3ml/sec
90. Which one of the following is the principal organ for drug excretion?
Correct : C. Kidneys
91. Compounds excreted in bile is classified into 3 categories. Which one of the following does not come
under the categories?
Correct : D. Drugs with bile/plasma concentration ratio above 1000
92. What is the molecular weight cut off for biliary excretion?
Correct : B. More than 300 Dalton
93. What is the equation for biliary clearance?
Correct : B. Biliary excretion rate/ plasma drug concentration
94. For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
Correct : B. 1.75 ml/mm
95. Which compounds are excreted through the lungs?
Correct : B. Gaseous
96. What is the pH of the milk secreted by human mothers?
Correct : A. 6.4-7.6
97. What is the mechanism of drug excretion for skin excretion?
Correct : C. Passive diffusion
98. What is the mechanism of drug excretion for biliary excretion?
Correct : A. Active secretion
99. Which of the following is not a factor influencing pulmonary excretion?
Correct : D. Heart rate
100. How is renal clearance expressed mathematically?
Correct : A. Rate of urinary excretion/plasma drug concentration