1. Which of the following drug is not intended for pulmonary administration?
Correct : C. NSAIDs
2. A drug in the concentrated injection is absorbed faster.
Correct : A. True
3. Intramuscular drug absorption is faster than intravascular.
Correct : B. False
4. Several factors such as the thickness of stratum corneum, presence of hair follicles, trauma, hydration of the skin, Grooming, exposure to chemicals determine the passive absorption of drugs from the surface of the skin to below.
Correct : A. True
5. Which process involve alteration of drug distribution
Correct : C. Both
6. If drug have very small volume of distribution it is likely that the drug
Correct : B. Does not accumulate in various tissue and organ
7. If distribution of drug is slower than process of biotransformation and elimination
Correct : C. Cause failure to attain diffusion equilibrium
8. If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given
statement is true?
Correct : B. Free concentration of drug X in blood will be increase
9. The distribution of drugs into the central nervous system (brain) usually depends on:
Correct : A. Aqueous diffusion
10. Which of the following is most likely to be associated with a high apparent volume of distribution
Correct : D. Extensive binding to tissue constituents
11. The Initial distribution of drug into the tissue is determined chiefly by
Correct : A. Rate of blood flow to tissue
12. Transfer of drug from plasma to tissue depends on
Correct : B. Blood perfusion rate of tissue
13. A hydrophilic medicinal agent has
Correct : A. Low ability to penetrate through the cell membrane lipids
14. Biological barriers include all except:
Correct : A. Renal tubules
15. Blood Brain Barrier is maximum permeable to
Correct : B. C02
16. If a CNS drug is extensively ionized at pH of blood it will
Correct : A. Penetrate the blood brain barrier slowly
17. The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following
except
Correct : A. Drug size (diffusion constant)
18. The formula to calculate half life (t1/2) is
Correct : A. 0.693 *Vd / C1
19. The procedure of transporting a drug from the bloodstream to tissues is called as
Correct : C. Distribution
20. …………..it represents the degree to which a drug is distributed in body tissue rather than
Correct : A. Volume of distribution (YD)
21. It is defined as the distribution of a drug between plasma and the rest of the body after oral or
parenteral dosing.
Correct : B. Apparent volume of drug distribution
22. The drugs having molecular size …………..easily cross capillary membrane.
Correct : A. <500-600d
23. The concentration of drug in blood or plasma will be comparatively in the GI tract.
Correct : B. Low
24. Fat is act as reservoir for……………………… Drugs
Correct : C. Highly lipid soluble
25. Displacement is significant when, the displaced drug is more than protein bound.
Correct : B. 95%
26. ……………is located at the sertoli-sertoli cell junction.
Correct : A. Blood testis barrier
27. The Binding Order of drug to tissue is…………………
Correct : C. Liver > Kidney > Lungs > Muscle
28. …………………in lipophilicity increases the extend of binding.
Correct : A. Increase
29. Protein binding of drugs helps to maintain ……………for absorption of drugs.
Correct : B. sink condition
30. The loading dose of a drug is based upon the
Correct : D. apparent volume of distribution and the desired drug concentration in plasma
31. The volume of distribution of drugs is:
Correct : C. A relationship between the total amount of drug in the body and the concentration of the drug in the blood
32. The volume of distribution (Vd) relates:
Correct : D. The amount of a drug in the body to the concentration of a drug in plasma
33. Movement of drug across the membrane is called as
Correct : C. Drug transport
34. Which of the following is known as Tamoxifen binding site?
Correct : D. Site IV
35. Which of the following drug selectively bound to extravascular tissues?
Correct : D. Chloroquin
36. Plasma Protein binding …………..the volume of distribution of drugs.
Correct : B. decreases
37. Following intravenous administration, drugs are distributed fastest to:
Correct : B. the liver, kidney, and brain
38. …………is the tight junction between sertoli cells.
Correct : C. blood-testis barrier
39. Distribution is……………..
Correct : B. dynamic equilibrium process
40. A drug reverses plasma-protein binding is often referred as……..
Correct : A. displacer
41. Primary binding site for albumin is ………………binding site.
Correct : A. Warfarin
42. Which of the following strategies are widely used to improve or promote transport of drug to brain?
Correct : D. All of the above
43. Acidic drug have
Correct : A. Low Vd
44. Low molecular weight of drugs have
Correct : B. high Vd
45. Water soluble drugs have
Correct : A. Low Vd
46. Lipid soluble drugs have
Correct : B. high Vd
47. Protein binding ……………the distribution of drugs.
Correct : A. Decreases
48. Which one of the following physicochemical property is more important for passive diffusion of drugs from the GIT?
Correct : A. Partition coefficient
49. Drug permeation through BBB can be improved by………..
Correct : D. all of the above
50. Which of the following drug diffuses readily into the brain?
Correct : B. Thiopental
51. Drug distribution in an organ depends on…………
Correct : D. all of the above
52. Protein binding of acidic drugs decreased in………..
Correct : A. Trauma
53. Which one of the following sentences will be the actual definition of distribution?
Correct : D. Reversible tr
54. What should be the molecular weight of the drug molecules so that they can easily pass through the membrane?
Correct : B. 500-600 Dalton
55. Which type of drug cannot enter the cell membrane in the below picture?
Correct : A. Ionized drug
56. Which drugs cannot pass the Capillary endothelial Barrier?
Correct : B. Drugs bound to blood components
57. Which of the following drug cannot pass through the plasma membrane barrier?
Correct : D. Drug size more than 600 Dalton
58. Which cell make up the blood-brain barrier?
Correct : D. Endothelial cells
59. What is the name of the specialized cells that support the blood-brain barrier tissue?
Correct : A. Astrocytes
60. Why dopamine cannot be administered for the disease Parkinsonism?
Correct : C. Cannot cross the blood-brain barrier
61. Which one of these is not an approach to make the drug cross the blood-brain barrier?
Correct : C. Use of highly lipophilic drug only
62. Which drugs can easily pass the Placental barrier?
Correct : C. Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics
63. What is the function of the blood-testis barrier?
Correct : D. Restricts the passage of drugs to spermatocytes and spermatids
64. What is the perfusion rate?
Correct : C. The volume of blood that flows per unit time per unit volume of tissue
65. Who has more intracellular and extracellular water more in their body?
Correct : C. Infants
66. Who has higher fat content?
Correct : C. Infants and elders
67. Who has poorly developed BBB?
Correct : A. Infants
68. During pregnancy, drug distribution is more. Which of the following sentences describe the given fact better?
Correct : D. The growth of the uterus, placenta, and foetus increases the volume thus increasing distribution. And even the baby forms a separate compartment for a drug to get distributed
69. What happens when an obese person is given with a lipophilic drug?
Correct : C. High adipose tissue take up most of the lipophilic drug
70. What is the consequence of diet high in fats?
Correct : D. The high fatty acid level affect the binding of acidic drugs
71. The extent to which a drug is distributed is a tissue depends upon ___________ and _____________
Correct : B. Tissue volume, tissue/blood partition coefficient of drug
72. Which one of the following has a high perfusion rate?
Correct : C. Lungs and kidney
73. Which one of the following has very low perfusion rate?
Correct : A. Fat and bone
74. Infants have high albumin content.
Correct : B. False
75. Disease state of a patient can influence drug distribution across the body.
Correct : A. True
76. In meningitis and encephalitis polar antibiotics gain access to BBB which don’t happen to a healthy
person.
Correct : A. True
77. What reasons make tissue-drug binding important for drug distribution?
Correct : A. Increases the volume of distribution of drugs and results in localization of drug at a specific site
78. Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is
the correct order?
Correct : D. Liver > kidney > lung > muscle
79. What is the relation between halogenated hydrocarbon and liver?
Correct : C. Halogenated hydrocarbon causes hepatotoxicity
80. Which drugs accumulate in liver?
Correct : B. Basic drugs like imipramine
81. Which metals get accumulated in kidney?
Correct : A. Mercury, cadmium, lead
82. Which of the following drugs accumulate in skin?
Correct : D. Chloroquine
83. Which of the following drugs are responsible for retinopathy?
Correct : D. Chloroquinine
84. Which drugs deposit in hair shafts?
Correct : A. Arsenicals
85. Which drug causes brown yellow discoloration of infant’s teeth?
Correct : B. Tetracycline
86. Which drug accumulate in adipose tissue?
Correct : D. Lipophilic drug
87. Which drugs results in distortion of double stranded DNA structure?
Correct : B. Quinacrine
88. In equation X=Vd C, what does Vd denotes?
Correct : D. The volume of the body fluid in which the drug is getting dissolved
89. The amount of drug in the body is directly proportional to the concentration of the drug in plasma.
Correct : A. True
90. The body water has 3 distinct compartments. Which one of these is not one of the compartments?
Correct : D. Between the tissue layers
91. How can you determine the extracellular fluid volume?
Correct : B. Na+
92. How a patient’s plasma volume can be determined?
Correct : A. Evans blue
93. The total body water volume can be determined by using high molecular weight dyes.
Correct : B. False
94. How will you determine the intracellular fluid volume?
Correct : C. Difference between total body water and ECF volume
95. What will be the apparent volume of distribution of warfarin?
Correct : A. The apparent volume of distribution is less than the true volume of distribution
96. What will bet the apparent volume of distribution of drugs which binds selectively to extravascular tissues?
Correct : B. The apparent volume of distribution is more than the true volume of distribution
97. Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.
Correct : A. True
98. Which one of the following bonds is not generally a bond through which a drug will bind in our body?
Correct : D. Covalent bond
99. Binding of drugs falls into 2 components those are _______________
Correct : A. Binding of drugs to blood components and to extravascular tissue
100. Which one of the following is the correct order of the drugs binding to various plasma protein?
Correct : C. Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins