1. The process by which molecules diffuse from a region of higher concentration to a region of lower
concentration and no external energy is expended is called
Correct : A. Passive diffusion
2. Which law states that 'the rate of diffusion is proportional to both the surface area and concentration
difference and is inversely proportional to the thickness of the membrane’?
Correct : A. Fick's Law
3. Which of the following is a not mechanism of drug absorption through GIT
Correct : D. Metastasis
4. The process of engulfing of particulate material is called
Correct : B. Phagocytosis
5. Which of the following process is also called "cell drinking"?
Correct : A. Pinocytosis
6. The absorption of drugs like (quaternary ammonium compounds, sulphonic acid) are explained by
Correct : A. Ion pair transport
7. Fick's law is used for study of
Correct : D. Diffusion rate
8. The delivery of a drug through the skin is known as
Correct : B. Transdermal
9. Which route of drug administration shows 100% Bioavailability?
Correct : B. Intravenous
10. If drug administered by Intravenous route appears in feaces, it implies that the drug
Correct : B. Undergoes enterohepatic recycling
11. Which of the following is characteristic of the oral route?
Correct : A. Absorption depends on GI tract secretion and motor function
12. When the active transport system become saturated, the rate process become
Correct : A. Zero order
13. Rate of absorption of drug by passive diffusion is maximum in
Correct : A. Small intestine
14. Maximum movement of drug across the membrane occurs by
Correct : B. Unionised
15. If drug has pKa value of 3 then at pH value of 7 what would be the degree of ionisation of the drug?
Correct : A. Majority portion would be ionised
16. Which of the following is not the characteristic of the carrier mediated transport system?
Correct : B. Reach equilibrium
17. Which of the following is alimentary route of administration when passage of drug through liver is
minimized?
Correct : C. Rectal
18. ………………is the process of movement of unchanged drug from the site of administration to the
systemic circulation.
Correct : A. Absorption
19. Energy is utilized in ………………… diffusion mechanism.
Correct : B. Active
20. ……………… involves the engulfment of small molecules or fluid.
Correct : B. Pinocytosis
21. The concentration of drug in blood or plasma will be comparatively in the GI tract.
Correct : A. High
22. ................mechanism is useful to describe charged or highly ionized drug molecules.
Correct : A. Ion-pair transport
23. To avoid bioavailability issues, the drug must have a minimum aqueous solubility of
Correct : D. 1%
24. When the solvent molecules are entrapped in the crystalline structure of the polymorph, it is called as
Correct : A. Pseudo-polymorphism
25. The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product.
The above give statement is?
Correct : A. True
26. The order of dissolution and absorption for different solid dosage forms is
Correct : B. Amorphous > meta-stable > stable
27. According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach
because the drug which exists primarily in the………….
Correct : A. un-ionised, more lipid soluble form
28. Noyes and Whitney equation is used to describe____________
Correct : B. Dissolution
29. Amorphous forms of drugs are
Correct : B. more soluble than crystal forms
30. Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate?
Correct : A. Cyclodextrins
31. Drugs undergoing first pass metabolism are advised not to be administered through
Correct : D. Tr
32. When the solvent in association with the drug is water, the solvate is known as
Correct : C. hydrate
33. ………….is used to study gastric emptying.
Correct : A. Barium sulphate
34. The main mechanism of most drugs absorption in GI tract is:
Correct : D. Passive diffusion (lipid diffusion)
35. Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized:
Correct : C. Rectal
36. What is characteristic of the oral route?
Correct : B. Absorption depends on GI tract secretion and motor function
37. Tick the feature of the sublingual route:
Correct : A. Pretty fast absorption
38. Pick out the parenteral route of medicinal agent administration:
Correct : D. Inhalation
39. Parenteral administration:
Correct : C. Usually produces a more rapid response than oral administration
40. What is characteristic of the intramuscular route of drug administration?
Correct : B. Oily solutions can be injected
41. All are characteristics of passive diffusion except
Correct : C. Drugs moves up the concentration gradient.
42. Passive diffusion is expressed by
Correct : A. Fick's first law of diffusion
43. Aqueous filled pores present in cell membrane responsible for absorption of
Correct : B. water soluble molecules
44. What kind of substances cannot permeate membranes by passive diffusion?
Correct : D. Hydrophilic substances
45. A hydrophilic medicinal agent has the following property:
Correct : A. Low ability to penetrate through the cell membrane lipids
46. What is implied by active transport?
Correct : A. Transport of drugs through a membrane by means of diffusion
47. The rate of diffusion of drug across biological membrane is
Correct : A. Directly proportional to the concentration gradients
48. Absorption of griseofulvin is……………
Correct : A. Dissolution rate limited
49. Micronized form of drug absorbed fast because
Correct : A. surface area increased
50. …………form of weakly acidic drug absorbed well in stomach
Correct : B. unionised
51. According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach
because the drug which exist primarily in the
Correct : A. Unionized, more lipid soluble form
52. Very weak bases having pKa < 5
Correct : C. Are unionized at all pH values
53. IV route of drug administration does not involve…………
Correct : B. absorption step
54. In carrier mediated transport energy is derived from……..
Correct : A. Hydrolysis of ATP
55. Which of the following drug is not stable in the gastric fluid?
Correct : A. Erythromycin
56. ………types of drugs are absorbed by pore transport mechanism.
Correct : D. Water soluble drugs of molecular weight less than 100
57. Area in which the carrier system is most dense is called as…………..
Correct : D. Absorption window
58. Which of the following is carrier mediated transport system
Correct : B. active transport
59. Absorption of poorly soluble drug is
Correct : B. dissolution rate limited
60. Which of the following process drug moves from site of administration to systemic circulation?
Correct : B. absorption
61. Based on Henderson-Hasselbalch equation, at what pH value a weak acid would be 99.9% ionized?
Correct : B. At pH equivalent to pKa + 3
62. In passive diffusion, the transport of drugs takes place from a region of ……………concentration to a ……………..concentration.
Correct : B. Higher, Lower
63. Which is the major process of absorption for more than 90% of drugs?
Correct : D. Passive diffusion
64. What is the driving force for Passive Diffusion?
Correct : D. Concentration and Electrochemical gradient both
65. Which kind of molecules cannot pass through a pore transport?
Correct : D. Molecules greater than 400 Dalton
66. What is the driving force of Pore Transport?
Correct : A. Hydrostatic pressure
67. What will be the best definition for “carrier”?
Correct : B. Carrier binds reversibly and no covalently with the molecules
68. What is the major difference between Facilitated diffusion and Passive diffusion?
Correct : A. Carrier-mediated transport
69. What influences the permeation of drugs in an Ionic or Electrochemical diffusion?
Correct : A. Charge on the membrane
70. Which kind of drugs are absorbed through endocytosis?
Correct : C. Macromolecular drugs or drugs as oily droplets
71. Which drugs are absorbed through pore transport?
Correct : B. Water-soluble drugs of molecular weight less than 100 Dalton
72. Which types of drugs get absorbed by ion-pair transport?
Correct : D. Drugs that ionize at all pH conditions
73. Which of these absorption methods involves engulfing of the extracellular drug?
Correct : A. Endocytosis
74. Which is the other name of “cell eating”?
Correct : B. Phagocytosis
75. Transfer of an endocytic vesicle from one extracellular compartment to another is known as
Correct : B. Transcytosis
76. A drug can be absorbed by more than one mechanism.
Correct : A. True
77. Which kind of absorption mechanism is showing in the picture?
Correct : B. Passive transport
78. Which one of these is a physicochemical property of Drug substance?
Correct : A. Drug solubility
79. Which one of these does not come under a physicochemical property of drugs?
Correct : B. Disintegration time
80. In the sequence of events in the drug absorption from orally administered solid dosage, which one
comes at first?
Correct : A. Disintegration
81. Which one is the correct sequence for drug absorption through the oral route?
Correct : C. Disintegration – Deaggregation – Dissolution – Absorption
82. Patient-related factors of drug absorption do not deal with which one of these?
Correct : D. Pharmaceutic ingredients
83. The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. This is known as ____________
Correct : C. Rate limiting step
84. Diffusion coefficient of drug D, Greater the value faster us the dissolution.
Correct : A. True
85. Greater the surface area lesser is the dissolution.
Correct : B. False
86. Which one of the following is a critical rate-limiting step of drug absorption?
Correct : D. Rate of dissolution
87. Which sentence will define the Dissolution rate?
Correct : D. Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area
88. What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?
Correct : D. 1-2 mg/ml
89. Which one of these is not a theory of Drug dissolution?
Correct : B. Fick’s law of diffusion
90. Which theory takes into account that a thin film is created by the solution of the solid at the solidliquid interface?
Correct : B. Diffusion layer model
91. In the equation G=Ki (Cs-Cb), what does G stands for______________
Correct : A. Dissolution rate per unit area
92. Which model does not approve the existence of the stagnant layer in the solid-liquid interface?
Correct : D. Danckwert’s model
93. What does the interfacial barrier model states?
Correct : A. An intermediate concentration exists at the interface
94. In the equation, Wo1/3-W1/3=Kt, K stands for ____________
Correct : C. Dissolution constant
95. Which are the two rate-determining step of drug absorption when given orally?
Correct : C. Dissolution and permeation through the membrane
96. The maximum amount of solute dissolved in a given solvent under standard conditions of temperature, pressure, and pH is known as __________
Correct : D. Absolute or intrinsic solubility
97. In the equation, V dC/dt = dm/dt = A(Cs-Cb).√ γ D, what does γ stands for?
Correct : B. Rate of surface renewal
98. Each face of the crystal has a different interfacial barrier.
Correct : A. True
99. Absorption of drugs can be categorized into 2 classes, physicochemical properties of drugs and Dosage form of the drug, on the basis of drug dissolution.
Correct : A. True
100. Which option will be the best example of the physicochemical properties of drugs?
Correct : D. Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability